Hydrogel Micropillars with Integrin Selective Peptidomimetic Functionalized Nanopatterned Tops: A New Tool for the Measurement of Cell Traction Forces Transmitted through αvβ3‐ or α5β1‐Integrins. (5th August 2013)

• Record Type: Journal Article
• Authors: Rahmouni, Sabri; Lindner, Aaron; Rechenmacher, Florian; Neubauer, Stefanie; Sobahi, Tariq Rashad Ali; Kessler, Horst; Cavalcanti‐Adam, Elisabetta Ada; Spatz, Joachim Pius
• Is Part Of: Advanced materials. Volume 25:Number 41(2013)
• Page Start: 5869
• Page End: 5874
• Publication Date: 2013-08-05
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201301338
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201301338-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Poly(ethylene glycol) micropillars</bold> with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α₅ β₁‐ and α_vβ₃‐ integrins. Cells adherent via α₅ β₁‐integrins have a tendency to exert higher maximum forces than cells adhering <italic>via</italic> α_vβ₃‐integrins. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3t123gr8" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>