Facile biocatalytic synthesis of a macrocyclic lactone in sub- and supercritical solvents. (March 2014)

• Record Type: Journal Article
• Authors: Karmee, Sanjib Kumar; Niemeijer, Bernd; Casiraghi, Laura; Mlambo, Benhilda; Lapkin, Alexei; Greiner, Lasse
• Is Part Of: Biocatalysis and biotransformation. Volume 32:Number 2(2014)
• Page Start: 125
• Page End: 131
• Publication Date: 2014-03
• Subjects: Enzymes -- Biotechnology -- Periodicals; Enzymes -- Industrial applications -- Periodicals; Biotransformation (Metabolism) -- Periodicals; 660.63
• DOI: 10.3109/10242422.2014.893579
• Languages: English
• ISSNs: 1024-2422

Abstract

<abstract> <title>Abstract</title> <p>High yield and selectivity in the intramolecular synthesis of the macrocyclic lactone oxacyclohexadecan-2-one were achieved via a straightforward biocatalytic synthesis utilising non-conventional solvents: supercritical carbon dioxide (scCO₂), ethane, fluoroform and 1, 1, 1, 2-tetrafluoroethane. Batch and continuous syntheses were demonstrated with a higher yield attained in a continuous synthesis using in-situ product extraction by scCO₂. A remarkably high yield was obtained in 1, 1, 1, 2-tetrafluoroethane at batch conditions.</p> </abstract>