PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox‐Sensitive Protein. (31st October 2013)

• Record Type: Journal Article
• Authors: Apanasets, Oksana; Grou, Cláudia P.; Van Veldhoven, Paul P.; Brees, Chantal; Wang, Bo; Nordgren, Marcus; Dodt, Gabriele; Azevedo, Jorge E.; Fransen, Marc
• Is Part Of: Traffic. Volume 15:Number 1(2014:Jan.)
• Page Start: 94
• Page End: 103
• Publication Date: 2013-10-31
• Subjects: Biological transport -- Periodicals; 571.6
• DOI: 10.1111/tra.12129
• Languages: English
• ISSNs: 1398-9219

Abstract

<abstract abstract-type="graphical" id="tra12129-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="tra12129-para-0002">Mounting evidence suggests that oxidative stress impairs peroxisomal matrix protein import. This study provides direct evidence that the import of PTS1 matrix proteins into peroxisomes is indeed a redox‐regulated process, and that this redox‐sensitivity is mediated by PEX5, the shuttling receptor for PTS1 proteins. In addition, it demonstrates that Cys11 of human PEX5 functions as a redox switch that modulates PEX5 activity in response to intracellular oxidative stress, most likely by modulating its monoubiquitination at the peroxisomal membrane. <boxed-text content-type="graphic" id="tra12129-blkfxd-0001" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg3zfsrgtf" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>