PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox‐Sensitive Protein. (31st October 2013) - Apanasets, Oksana
Abstract Mounting evidence suggests that oxidative stress impairs peroxisomal matrix protein import. This study provides direct evidence that the import of PTS1 matrix proteins into peroxisomes is indeed a redox‐regulated process, and that this redox‐sensitivity is mediated by PEX5, the shuttling receptor for PTS1 proteins. In addition, it demonstrates that Cys11 of human PEX5 functions as a redox switch that modulates PEX5 activity in response to intracellular oxidative stress, most likely by modulating its monoubiquitination at the peroxisomal membrane.