MED1101: A new dialdehydic compound regulating P2×7 receptor cell surface expression in U937 cells. (15th July 2013)

• Record Type: Journal Article
• Authors: Muzzachi, Stefania; Blasi, Antonella; Ciani, Elena; Favia, Maria; Cardone, Rosa A.; Marzulli, Domenico; Reshkin, Stephan J.; Merizzi, Giulia; Casavola, Valeria; Soleti, Antonio; Guerra, Lorenzo
• Is Part Of: Biology of the cell. Volume 105:Number 9(2013:Sep.)
• Page Start: 399
• Page End: 413
• Publication Date: 2013-07-15
• Subjects: Cytology -- Periodicals; Electron microscopy -- Periodicals; 571.6
• DOI: 10.1111/boc.201200088
• Languages: English
• ISSNs: 0248-4900

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="boc201200088-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>We demonstrated that the novel dialdehydic compound, MED1101, may act as a key modulator of monocyte inflammatory response. This occurs through induction of P2X7R internalisation, followed by impairment of the P2X7R‐dependent intracellular signalling transduction, as suggested by inhibition of Ca²⁺ influx, MAPK phosphorylation, production of pro‐inflammatory chemokines and monocyte migration/transmigration. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg36nqw9sg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>