MED1101: A new dialdehydic compound regulating P2×7 receptor cell surface expression in U937 cells. (15th July 2013) - Muzzachi, Stefania
Abstract We demonstrated that the novel dialdehydic compound, MED1101, may act as a key modulator of monocyte inflammatory response. This occurs through induction of P2X7R internalisation, followed by impairment of the P2X7R‐dependent intracellular signalling transduction, as suggested by inhibition of Ca2+ influx, MAPK phosphorylation, production of pro‐inflammatory chemokines and monocyte migration/transmigration.