Iodine‐131 radiolabeling of poly ethylene glycol‐coated gold nanorods for in vivo imaging. (28th December 2012)

• Record Type: Journal Article
• Authors: Eskandari, Najmeh; Yavari, Kamal; Outokesh, Mohammad; Sadjadi, Sodeh; Ahmadi, Seyed Javad
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 56:Number 1(2013)
• Page Start: 12
• Page End: 16
• Publication Date: 2012-12-28
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3006
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Gold nanorods (GNRs) can be used in various biomedical applications; however, very little is known about their <italic>in vivo</italic> tissue distribution by radiolabeling. Here, we have developed a rapid and simple method with high yield and without disturbing their optical properties for radiolabeling of gold rods with iodine‐131 in order to track <italic>in vivo</italic> tissue uptake of GNRs after systemic administration by biodistribution analysis and γ‐imaging. Following intravenous injection into rat, PEGylated GNRs have much longer blood circulation times.</p> </abstract>