Iodine‐131 radiolabeling of poly ethylene glycol‐coated gold nanorods for in vivo imaging. (28th December 2012) - Eskandari, Najmeh
Abstract Gold nanorods (GNRs) can be used in various biomedical applications; however, very little is known about their in vivo tissue distribution by radiolabeling. Here, we have developed a rapid and simple method with high yield and without disturbing their optical properties for radiolabeling of gold rods with iodine‐131 in order to track in vivo tissue uptake of GNRs after systemic administration by biodistribution analysis and γ‐imaging. Following intravenous injection into rat, PEGylated GNRs have much longer blood circulation times.