Inhibitory effect of unicellular green algae (Chlorella vulgaris) water extract on allergic immune response. (5th April 2013)

• Record Type: Journal Article
• Authors: Bae, Min‐Jung; Shin, Hee Soon; Chai, Ok Hee; Han, Jae‐Gab; Shon, Dong‐Hwa
• Is Part Of: Journal of the science of food and agriculture. Volume 93:Number 12(2013:Sep. 15)
• Page Start: 3133
• Page End: 3136
• Publication Date: 2013-04-05
• Subjects: Food -- Periodicals; Agriculture -- Periodicals; 664
• DOI: 10.1002/jsfa.6114
• Languages: English
• ISSNs: 0022-5142

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jsfa6114-sec-0001" sec-type="section"> <title>Background</title> <p> <bold> <italic>Chlorella</italic> is used as a functional food in East Asia and has been shown to enhance immune system function. However, there has been no direct evidence of the suppressive effect of a hot water extract of <italic>Chlorella vulgaris</italic> (CVE) on histamine‐mediated allergic responses</bold>.</p> </sec> <sec id="jsfa6114-sec-0002" sec-type="section"> <title>Results</title> <p> <bold>The antihistamine activity of CVE was analysed using rat peritoneal mast cells (RPMCs) stimulated by compound 48/80. For <italic>in vivo</italic> verification, ovalbumin (OVA)‐immunised BALB/c mice were treated with CVE orally. Serum immunoglobulin E (IgE) levels and splenocyte cytokine levels were determined by enzyme‐linked immunosorbent assay (ELISA). CVE prevented histamine release through degranulation of mast cells by blocking the uptake of extracellular Ca<sup>2+</sup> into RPMCs. Moreover, CVE administration inhibited serum IgE overproduction by OVA via induction of T helper 1 (Th1) skewing that was dependent on interferon‐<italic>γ</italic> (IFN‐<italic>γ</italic>) and interleukin 12 (IL‐12) secretion</bold>.</p> </sec> <sec id="jsfa6114-sec-0003" sec-type="section"> <title>Conclusion</title> <p> <bold>The results of this study clearly demonstrate that CVE acts as an antiallergic dietary agent by suppressing histamine release via its enhancive effect on Th1‐related responses. © 2013 Society of Chemical Industry</bold> </p> </sec> </abstract>