Cholesterol modulation of protein function : sterol specificity and indirect mechanisms /: sterol specificity and indirect mechanisms. (2019)

• Record Type: Book
• Further Information: Note: Avia Rosenhouse-Dantsker, Anna N. Bukiya, editors.
• Editors: Rosenhouse-Dantsker, Avia; Bukiya, Anna N
• Contents: Intro; Preface; Contents; Contributors; Part I: Sterol Specificity in Modulating Protein Function; Chirality Effect on Cholesterol Modulation of Protein Function; 1 Introduction; 2 Chemical Structure and Synthesis; 3 Differential Effects of Cholesterol and Its Stereoisomers; 3.1 Effects on Membrane Proteins; 3.2 Effects on Lipid-Modified Proteins; 3.3 Effects on Sterol-Lipid Interactions; 3.4 Effects In Vivo; 4 Summary and Future Considerations; References; A Critical Analysis of Molecular Mechanisms Underlying Membrane Cholesterol Sensitivity of GPCRs 1 G Protein-Coupled Receptors as Signaling Hubs and Drug Targets2 Membrane Cholesterol in GPCR Function; 3 Strategies to Explore Cholesterol Sensitivity of GPCRs; 3.1 Solubilization and Reconstitution; 3.2 Inhibition of Cholesterol Biosynthesis; 3.3 Specific Carriers; 3.4 Enzymatic Oxidation; 3.5 Complexing Agents; 4 Mechanisms of Cholesterol Sensitivity of GPCRs; 4.1 Specific Requirement of Membrane Cholesterol for GPCRs; 4.1.1 Serotonin1A Receptor; 4.1.2 Oxytocin Receptor; 4.1.3 Galanin Receptor; 4.1.4 Chemokine Receptors; 4.1.5 Bitter Taste Receptors 5.2 Serotonin1A Receptor5.3 Cholecystokinin Receptor; 6 Conclusions; References; Regulation of BK Channel Activity by Cholesterol and Its Derivatives; 1 Introduction; 2 BK Channels: Protein Structure, Macromolecular Subunit Composition, and Physiological Role; 3 Phenomenology of BK Channel Regulation by CLR; 3.1 BK Channel Function Modification by Manipulations of CLR Levels In Vivo; 3.2 BK Channel Function Modification by Manipulations of CLR Levels In Vitro; 4 Mechanisms and Sites of CLR Action on the BK Channel; 4.1 Cellular Mechanisms 4.2 Microdomain Mechanisms and Protein-Protein Interactions4.3 Contribution of Different Subunits to BK Channel Sensitivity to CLR; 4.4 Cell-Free Mechanisms: Use of CLR Derivatives; 4.5 CLR-Sensing Sites in the BK Alpha Subunit Protein; 5 CLR Modulation of BK Channel Responses to Alcohol; 6 Conclusions; References; Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K+ Channels; 1 Introduction; 2 Stereo-Specific Cholesterol Regulation of Kir2 Channels; 3 Stereo-Specific Interaction of Cholesterol with the Kir2.2 Cholesterol Binding Site
• Publisher Details: Cham, Switzerland : Springer
• Publication Date: 2019
• Extent: 1 online resource (x, 197 pages), illustrations (some color)
• Subjects: 572/.5795; Cholesterol; Proteins; Electronic books
• Languages: English
• ISBNs: 9783030042783; 3030042782
• Related ISBNs: 9783030042776
• Notes: Note: Online resource; title from PDF title page (SpringerLink, viewed January 24, 2019).
• Access Rights: Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK).
• Access Usage: Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force.