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Author/Creator Wood, Michael R.

1. Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4). (August 2015)

Authors:
Smith, Emery; Chase, Peter; Niswender, Colleen M.; Utley, Thomas J.; Sheffler, Douglas J.; Noetzel, Meredith J.; Lamsal, Atin; Wood, Michael R.; Conn, P. Jeffrey; Lindsley, Craig W.; Madoux, Franck; Acosta, Mary; Scampavia, Louis; Spicer, Timothy; Hodder, Peter
Journal:
Journal of biomolecular screening
Issue:
Volume 20:Number 7(2015)
Page Start:
858
Record Type:
Journal Article
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2. Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs. Issue 2 (15th January 2017)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B.; Weiner, Rebecca L.; Cho, Hyekyung P.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Brandon, Nicho...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 2(2017)
Page Start:
171
Record Type:
Journal Article
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3. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides. Issue 23 (1st December 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 23(2017)
Page Start:
5179
Record Type:
Journal Article
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4. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Issue 13 (1st July 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Bertron, Jeanette L.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E.; Conn, P. Jeffrey...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 13(2017)
Page Start:
2990
Record Type:
Journal Article
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5. Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]. Issue 17 (15th September 2018)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 28:Issue 17(2018)
Page Start:
3014
Record Type:
Journal Article
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6. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl)thieno[2, 3-d]pyrimidine core. Issue 13 (1st July 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Engers, Julie L.; Bollinger, Katrina A.; Melancon, Bruce J.; Tarr, James C.; Han, Changho; West, Mary; Gregro, Alison R.; Lamsal, Atin; Chang, Sichen; Ajmera, Sonia; Smith, Emery; Chase, Peter; Hodder, Peter S.; Bubser, Michael; Jones, Carrie K.; Hopkins, C...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 13(2016)
Page Start:
3029
Record Type:
Journal Article
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7. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Issue 17 (1st September 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Tarr, James C.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Foster, Jarrett J.; Smith, Emery; Chase, Peter; Hodder, Peter S.; Engers, Darren W.; Niswender, Colleen M.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 17(2016)
Page Start:
4282
Record Type:
Journal Article
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8. Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)‐Selective M5‐Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe. Issue 8 (1st April 2014)

Authors:
Gentry, Patrick R.; Kokubo, Masaya; Bridges, Thomas M.; Cho, Hyekyung P.; Smith, Emery; Chase, Peter; Hodder, Peter S.; Utley, Thomas J.; Rajapakse, Anuruddha; Byers, Frank; Niswender, Colleen M.; Morrison, Ryan D.; Daniels, J. Scott; Wood, Michael R.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
ChemMedChem
Issue:
Volume 9:Issue 8(2014:Aug.)
Page Start:
1677
Record Type:
Journal Article
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9. Further optimization of the M5 NAM MLPCN probe ML375: Tactics and challenges. Issue 3 (1st February 2015)

Authors:
Kurata, Haruto; Gentry, Patrick R.; Kokubo, Masaya; Cho, Hyekyung P.; Bridges, Thomas M.; Niswender, Colleen M.; Byers, Frank W.; Wood, Michael R.; Daniels, J. Scott; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 3(2015)
Page Start:
690
Record Type:
Journal Article
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10. Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands. Issue 3 (1st February 2019)

Authors:
Poslusney, Michael S.; Salovich, James M.; Wood, Michael R.; Melancon, Bruce J.; Bollinger, Katrina A.; Luscombe, Vincent B.; Rodriguez, Alice L.; Engers, Darren W.; Bridges, Thomas M.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 3(2019)
Page Start:
362
Record Type:
Journal Article
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