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Author/Creator Rodriguez, Alice L.

21. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes. Issue 4 (15th February 2020)

Authors:
Temple, Kayla J.; Long, Madeline F.; Engers, Julie L.; Watson, Katherine J.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 4(2020)
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Record Type:
Journal Article
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22. Further exploration of an N-aryl phenoxyethoxy pyridinone-based series of mGlu3 NAMs: Challenging SAR, enantiospecific activity and in vivo efficacy. Issue 18 (15th September 2019)

Authors:
Yamada, Yosuke; Yohn, Samantha E.; Gilliland, Kristen; Loch, Mathew T.; Schulte, Michael L.; Rodriguez, Alice L.; Blobaum, Anna L.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 18(2019)
Page Start:
2670
Record Type:
Journal Article
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23. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs. (15th January 2021)

Authors:
Davis, Dexter C.; Bungard, Joseph D.; Chang, Sichen; Rodriguez, Alice L.; Blobaum, Annie L.; Boutaud, Olivier; Melancon, Bruce J.; Niswender, Colleen M.; Jeffrey Conn, P.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 32(2021)
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Record Type:
Journal Article
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24. N-Alkylpyrido[1′, 2′:1, 5]pyrazolo-[4, 3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents. Issue 8 (15th April 2016)

Authors:
Felts, Andrew S.; Rodriguez, Alice L.; Morrison, Ryan D.; Venable, Daryl F.; Blobaum, Anna L.; Byers, Frank W.; Daniels, J. Scott; Niswender, Colleen M.; Jones, Carrie K.; Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 8(2016)
Page Start:
1894
Record Type:
Journal Article
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25. Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands. Issue 3 (1st February 2019)

Authors:
Poslusney, Michael S.; Salovich, James M.; Wood, Michael R.; Melancon, Bruce J.; Bollinger, Katrina A.; Luscombe, Vincent B.; Rodriguez, Alice L.; Engers, Darren W.; Bridges, Thomas M.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 3(2019)
Page Start:
362
Record Type:
Journal Article
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27. Positive allosteric modulators (PAMs) of the group II metabotropic glutamate receptors: Design, synthesis, and evaluation as ex-vivo tool compounds. (15th October 2021)

Authors:
Yamada, Yousuke; Gilliland, Kristen; Xiang, Zixiu; Haymer, Daniel; Crocker, Katherine E.; Loch, Matthew T.; Schulte, Michael L.; Rodriguez, Alice L.; Niswender, Colleen M.; Jeffrey Conn, P.; Lindsley, Craig W.; Melancon, Bruce J.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 50(2021)
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Record Type:
Journal Article
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28. SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs. Issue 16 (15th August 2019)

Authors:
Chopko, Trevor C.; Han, Changho; Gregro, Alison R.; Engers, Darren W.; Felts, Andrew S.; Poslusney, Mike S.; Bollinger, Katrina A.; Morrison, Ryan D.; Bubser, Michael; Lamsal, Atin; Luscombe, Vincent B.; Cho, Hyekyung P.; Schnetz-Boutaud, Nathalie C.; Rodriguez, Alice L.; Chang, Sichen; Daniels, ...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 16(2019)
Page Start:
2224
Record Type:
Journal Article
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29. Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278. Issue 10 (15th May 2019)

Authors:
Reed, Carson W.; Washecheck, Jordan P.; Quitlag, Marc C.; Jenkins, Matthew T.; Rodriguez, Alice L.; Engers, Darren W.; Blobaum, Anna L.; Conn, P. Jeffrey; Niswender, Colleen M.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 10(2019)
Page Start:
1211
Record Type:
Journal Article
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30. Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor. (15th January 2022)

Authors:
Bender, Aaron M.; Carter, Trever R.; Spock, Matthew; Rodriguez, Alice L.; Dickerson, Jonathan W.; Rook, Jerri M.; Chang, Sichen; Qi, Aidong; Presley, Christopher C.; Engers, Darren W.; Harp, Joel M.; Bridges, Thomas M.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 56(2022)
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Record Type:
Journal Article
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