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Author/Creator Rodriguez, Alice L.

1. Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]. Issue 17 (15th September 2018)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 28:Issue 17(2018)
Page Start:
3014
Record Type:
Journal Article
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2. Discovery of a novel 3, 4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 21 (1st November 2019)

Authors:
Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Gregro, Alison R.; Watson, Katherine J.; Chang, Sichen; Jenkins, Matthew T.; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 21(2019)
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Record Type:
Journal Article
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3. Discovery of a novel 2, 3-dimethylimidazo[1, 2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype. Issue 3 (1st February 2020)

Authors:
Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Watson, Katherine J.; Chang, Sichen; Luscombe, Vincent B.; Jenkins, Matthew T.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 3(2020)
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Journal Article
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4. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes. Issue 4 (15th February 2020)

Authors:
Temple, Kayla J.; Long, Madeline F.; Engers, Julie L.; Watson, Katherine J.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 4(2020)
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Record Type:
Journal Article
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5. Discovery and characterization of N-(1, 3-dialkyl-1H-indazol-6-yl)-1H-pyrazolo[4, 3-b]pyridin-3-amine scaffold as mGlu4 positive allosteric modulators that mitigate CYP1A2 induction liability. Issue 15 (15th August 2018)

Authors:
Engers, Darren W.; Bollinger, Sean R.; Engers, Julie L.; Panarese, Joseph D.; Breiner, Megan M.; Gregro, Alison; Blobaum, Anna L.; Bronson, Joanne J.; Wu, Yong-Jin; Macor, John E.; Rodriguez, Alice L.; Zamorano, Rocio; Conn, P. Jeffrey; Lindsley, Craig W.; Niswender, Colleen M.; Hopkins, Corey R.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 28:Issue 15(2018)
Page Start:
2641
Record Type:
Journal Article
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6. Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity. Issue 13 (1st July 2020)

Authors:
Fulton, Mark G.; Loch, Matthew T.; Rodriguez, Alice L.; Lin, Xin; Javitch, Jonathan A.; Conn, P. Jeffrey; Niswender, Colleen M.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 13(2020)
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Record Type:
Journal Article
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7. Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands. Issue 3 (1st February 2019)

Authors:
Poslusney, Michael S.; Salovich, James M.; Wood, Michael R.; Melancon, Bruce J.; Bollinger, Katrina A.; Luscombe, Vincent B.; Rodriguez, Alice L.; Engers, Darren W.; Bridges, Thomas M.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 3(2019)
Page Start:
362
Record Type:
Journal Article
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8. Discovery of a novel class of heteroaryl-pyrrolidinones as positive allosteric modulators of the muscarinic acetylcholine receptor M1. (1st September 2021)

Authors:
Spearing, Paul K.; Cho, Hyekyung P.; Luscombe, Vincent B.; Blobaum, Anna L.; Boutaud, Olivier; Engers, Darren W.; Rodriguez, Alice L.; Niswender, Colleen M.; Jeffrey Conn, P.; Lindsley, Craig W.; Bender, Aaron M.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 47(2021)
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Record Type:
Journal Article
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9. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2. (1st December 2021)

Authors:
Long, Madeline F.; Capstick, Rory A.; Spearing, Paul K.; Engers, Julie L.; Gregro, Alison R.; Bollinger, Sean R.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Cho, Hyekyung P.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.; Engers, Darren W.; Temple,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 53(2021)
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Journal Article
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10. Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor. (15th January 2022)

Authors:
Bender, Aaron M.; Carter, Trever R.; Spock, Matthew; Rodriguez, Alice L.; Dickerson, Jonathan W.; Rook, Jerri M.; Chang, Sichen; Qi, Aidong; Presley, Christopher C.; Engers, Darren W.; Harp, Joel M.; Bridges, Thomas M.; Niswender, Colleen M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 56(2022)
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Record Type:
Journal Article
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