1. Synthesis of 2′‐Fluorinated Northern Methanocarbacyclic (2′‐F‐NMC) Nucleosides and Their Incorporation Into Oligonucleotides. Issue 1 (27th January 2020) Authors: Akabane‐Nakata, Masaaki; Kumar, Pawan; Erande, Namrata D.; Matsuda, Shigeo; Manoharan, Muthiah Editors: Beaucage, Serge L.; Bergstrom, Donald E.; Herdewijn, Piet; Matsuda, Akira Journal: Current protocols in nucleic acid chemistry Issue: Volume 80:Issue 1(2020) Page Start: n/a Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo. Issue 3 (15th July 2021) Authors: Jahns, Hartmut; Taneja, Nate; Willoughby, Jennifer L S; Akabane-Nakata, Masaaki; Brown, Christopher R; Nguyen, Tuyen; Bisbe, Anna; Matsuda, Shigeo; Hettinger, Matt; Manoharan, Rajar M; Rajeev, Kallanthottathil G; Maier, Martin A; Zlatev, Ivan; Charisse, Klaus; Egli, Martin; Manoharan, Muthiah Journal: Nucleic acids research Issue: Volume 50:Issue 3(2022) Page Start: 1221 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization. Issue 12 (23rd June 2022) Authors: Schlegel, Mark K; Janas, Maja M; Jiang, Yongfeng; Barry, Joseph D; Davis, Wendell; Agarwal, Saket; Berman, Daniel; Brown, Christopher R; Castoreno, Adam; LeBlanc, Sarah; Liebow, Abigail; Mayo, Tara; Milstein, Stuart; Nguyen, Tuyen; Shulga-Morskaya, Svetlana; Hyde, Sarah; Schofield, Sally; Szeto, ... Journal: Nucleic acids research Issue: Volume 50:Issue 12(2022) Page Start: 6656 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates. Issue 19 (15th September 2017) Authors: Nair, Jayaprakash K.; Attarwala, Husain; Sehgal, Alfica; Wang, Qianfan; Aluri, Krishna; Zhang, Xuemei; Gao, Minggeng; Liu, Ju; Indrakanti, Ramesh; Schofield, Sally; Kretschmer, Philip; Brown, Christopher R.; Gupta, Swati; Willoughby, Jennifer L.S.; Boshar, Julie A.; Jadhav, Vasant; Charisse, Klau... Journal: Nucleic acids research Issue: Volume 45:Issue 19(2017) Page Start: 10969 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs. Issue 19 (14th October 2021) Authors: Schlegel, Mark K; Matsuda, Shigeo; Brown, Christopher R; Harp, Joel M; Barry, Joseph D; Berman, Daniel; Castoreno, Adam; Schofield, Sally; Szeto, John; Manoharan, Muthiah; Charissé, Klaus; Egli, Martin; Maier, Martin A Journal: Nucleic acids research Issue: Volume 49:Issue 19(2021) Page Start: 10851 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
6. Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing. Issue 18 (11th September 2021) Authors: Jahns, Hartmut; Degaonkar, Rohan; Podbevsek, Peter; Gupta, Swati; Bisbe, Anna; Aluri, Krishna; Szeto, John; Kumar, Pawan; LeBlanc, Sarah; Racie, Tim; Brown, Christopher R; Castoreno, Adam; Guenther, Dale C; Jadhav, Vasant; Maier, Martin A; Plavec, Janez; Egli, Martin; Manoharan, Mu... Journal: Nucleic acids research Issue: Volume 49:Issue 18(2021) Page Start: 10250 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
7. 5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger. Issue 35 (12th April 2019) Authors: Kumar, Pawan; Parmar, Rubina G.; Brown, Christopher R.; Willoughby, Jennifer L. S.; Foster, Donald J.; Babu, I. Ramesh; Schofield, Sally; Jadhav, Vasant; Charisse, Klaus; Nair, Jayaprakash K.; Rajeev, Kallanthottathil G.; Maier, Martin A.; Egli, Martin; Manoharan, Muthiah Journal: Chemical communications Issue: Volume 55:Issue 35(2019) Page Start: 5139 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
8. 5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates. (28th April 2016) Authors: Parmar, Rubina; Willoughby, Jennifer L. S.; Liu, Jingxuan; Foster, Donald J.; Brigham, Benjamin; Theile, Christopher S.; Charisse, Klaus; Akinc, Akin; Guidry, Erin; Pei, Yi; Strapps, Walter; Cancilla, Mark; Stanton, Matthew G.; Rajeev, Kallanthottathil G.; Sepp‐Lorenzino, Laura; Manoharan, Muthia... Journal: Chembiochem Issue: Volume 17:Number 11(2016) Page Start: 985 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
9. Inside Cover: 5′‐(E)‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates (ChemBioChem 11/2016). (3rd June 2016) Authors: Parmar, Rubina; Willoughby, Jennifer L. S.; Liu, Jingxuan; Foster, Donald J.; Brigham, Benjamin; Theile, Christopher S.; Charisse, Klaus; Akinc, Akin; Guidry, Erin; Pei, Yi; Strapps, Walter; Cancilla, Mark; Stanton, Matthew G.; Rajeev, Kallanthottathil G.; Sepp‐Lorenzino, Laura; Manoharan, Muthia... Journal: Chembiochem Issue: Volume 17:Number 11(2016) Page Start: 970 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
10. Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease. Issue 8 (14th March 2020) Authors: Kumar, Pawan; Degaonkar, Rohan; Guenther, Dale C; Abramov, Mikhail; Schepers, Guy; Capobianco, Marie; Jiang, Yongfeng; Harp, Joel; Kaittanis, Charalambos; Janas, Maja M; Castoreno, Adam; Zlatev, Ivan; Schlegel, Mark K; Herdewijn, Piet; Egli, Martin; Manoharan, Muthiah Journal: Nucleic acids research Issue: Volume 48:Issue 8(2020) Page Start: 4028 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗