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Author/Creator Kleinheinz, Tracy

1. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. (14th November 2019)

Authors:
Pillow, Thomas H.; Adhikari, Pragya; Blake, Robert A.; Chen, Jinhua; Del Rosario, Geoffrey; Deshmukh, Gauri; Figueroa, Isabel; Gascoigne, Karen E.; Kamath, Amrita V.; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R.; Latifi, Brandon; Leipold, Douglas D.; Sing Li, Chun; Li, Ruina; Mulvihill,...
Journal:
ChemMedChem
Issue:
Volume 15:Number 1(2020)
Page Start:
17
Record Type:
Journal Article
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2. Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα). Issue 4 (15th February 2020)

Authors:
Dragovich, Peter S.; Adhikari, Pragya; Blake, Robert A.; Blaquiere, Nicole; Chen, Jinhua; Cheng, Yun-Xing; den Besten, Willem; Han, Jinping; Hartman, Steven J.; He, Jintang; He, Mingtao; Rei Ingalla, Ellen; Kamath, Amrita V.; Kleinheinz, Tracy; Lai, Tommy; Leipold, Douglas D.; Li, Chun Sing; Liu,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 4(2020)
Page Start:
Record Type:
Journal Article
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3. Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Issue 16 (15th August 2019)

Authors:
Labadie, Sharada S.; Li, Jun; Blake, Robert A.; Chang, Jae H.; Goodacre, Simon; Hartman, Steven J.; Liang, Weiling; Kiefer, James R.; Kleinheinz, Tracy; Lai, Tommy; Liao, Jiangpeng; Ortwine, Daniel F.; Mody, Vidhi; Ray, Nicholas C.; Roussel, Fabien; Vinogradova, Maia; Yeap, Siew Kuen; Zhang, Biro...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 16(2019)
Page Start:
2090
Record Type:
Journal Article
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4. Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer. (15th October 2021)

Authors:
Zbieg, Jason R.; Liang, Jun; Li, Jun; Blake, Robert A.; Chang, Jae; Friedman, Lori; Goodacre, Simon; Hartman, Steven J.; Rei Ingalla, Ellen; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada; Lai, Tommy; Liao, Jiangpeng; McLean, Nev; Metcalfe, Ciara; Mody, Vidhi; Nannini, Michelle; Ortwine, D...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 50(2021)
Page Start:
Record Type:
Journal Article
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5. Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2. Issue 4 (15th February 2019)

Authors:
Shore, Daniel G.M.; Sweeney, Zachary K.; Beresford, Alan; Chan, Bryan K.; Chen, Huifen; Drummond, Jason; Gill, Andrew; Kleinheinz, Tracy; Liu, Xingrong; Medhurst, Andrew D.; McIver, Edward G.; Moffat, John G.; Zhu, Haitao; Estrada, Anthony A.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 4(2019)
Page Start:
674
Record Type:
Journal Article
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6. Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity (ChemMedChem 1/2020). (13th January 2020)

Authors:
Pillow, Thomas H.; Adhikari, Pragya; Blake, Robert A.; Chen, Jinhua; Del Rosario, Geoffrey; Deshmukh, Gauri; Figueroa, Isabel; Gascoigne, Karen E.; Kamath, Amrita V.; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R.; Latifi, Brandon; Leipold, Douglas D.; Sing Li, Chun; Li, Ruina; Mulvihill,...
Journal:
ChemMedChem
Issue:
Volume 15:Number 1(2020)
Page Start:
1
Record Type:
Journal Article
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7. Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Issue 7 (1st April 2019)

Authors:
Zhang, Birong; Kiefer, James R.; Blake, Robert A.; Chang, Jae H.; Hartman, Steven; Ingalla, Ellen Rei; Kleinheinz, Tracy; Mody, Vidhi; Nannini, Michelle; Ortwine, Daniel F.; Ran, Yingqing; Sambrone, Amy; Sampath, Deepak; Vinogradova, Maia; Zhong, Yu; Nwachukwu, Jerome C.; Nettles, Kendall W.; Lai...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 7(2019)
Page Start:
905
Record Type:
Journal Article
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