Discovery of potent azaindazole leucine-rich repeat kinase 2 (LRRK2) inhibitors possessing a key intramolecular hydrogen bond – Part 2. Issue 4 (15th February 2019)

• Record Type: Journal Article
• Authors: Shore, Daniel G.M.; Sweeney, Zachary K.; Beresford, Alan; Chan, Bryan K.; Chen, Huifen; Drummond, Jason; Gill, Andrew; Kleinheinz, Tracy; Liu, Xingrong; Medhurst, Andrew D.; McIver, Edward G.; Moffat, John G.; Zhu, Haitao; Estrada, Anthony A.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 29:Issue 4(2019)
• Page Start: 674
• Page End: 680
• Publication Date: 2019-02-15
• Subjects: LRRK2 -- Kinase inhibitor -- Azaindazole -- Parkinson's disease -- Brain penetration; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2018.10.017
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: A series of potent azaindazole inhibitors of LRRK2 was discovered. A putative intramolecular hydrogen bond was crucial for LRRK2 potency. Optimization led to potent, metabolically stable, and brain-permeable molecules. Compound18 showed excellent LRRK2 potency and properties. Abstract: The discovery of disease-modifying therapies for Parkinson's Disease (PD) represents a critical need in neurodegenerative medicine. Genetic mutations in LRRK2 are risk factors for the development of PD, and some of these mutations have been linked to increased LRRK2 kinase activity and neuronal toxicity in cellular and animal models. As such, research towards brain-permeable kinase inhibitors of LRRK2 has received much attention. In the course of a program to identify structurally diverse inhibitors of LRRK2 kinase activity, a 5-azaindazole series was optimized for potency, metabolic stability and brain penetration. A key design element involved the incorporation of an intramolecular hydrogen bond to increase permeability and potency against LRRK2. This communication will outline the structure-activity relationships of this matched pair series including the challenge of obtaining a desirable balance between metabolic stability and brain penetration.