1. Design and rationale of two phase 3 randomised controlled trials (COUGH-1 and COUGH-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough. Issue 4 (2nd November 2020) Authors: Muccino, David R.; Morice, Alyn H.; Birring, Surinder S.; Dicpinigaitis, Peter V.; Pavord, Ian D.; Assaid, Christopher; Kleijn, Huub Jan; Hussain, Azher; La Rosa, Carmen; McGarvey, Lorcan; Smith, Jaclyn A. Journal: ERJ open research Issue: Volume 6:Issue 4(2020) Page Start: Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
2. Early stage development of the glycine‐1 re‐uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men. (20th May 2013) Authors: Liem‐Moolenaar, Marieke; Peeters, Pierre; Kamerling, Ingrid M. C.; Hogg, Chris; Holder, Graham; Kleijn, Huub Jan; Spaans, Edwin; Udo De Haes, Joanna; de, Marieke L.; Franson, Kari L.; Cohen, Adam F.; van, Joop M. A. Journal: British journal of clinical pharmacology Issue: Volume 75:Number 6(2013:Jun.) Page Start: 1455 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
3. Making Better Dose Decisions: Using Exposure‐Response Modeling to Integrate Efficacy Outcome of Two Phase IIb Clinical Trials of Ubrogepant for Migraine Treatment. Issue 3 (16th January 2020) Authors: Li, Chi‐Chung; Voss, Tiffini; Kowalski, Ken; Yang, Bei; Kleijn, Huub Jan; Jones, Christopher J.; Bosch, Rolien; Michelson, David; DeAngelis, Matthew; Xu, Yang; Xie, Iris; Kothare, Prajakti A. Journal: Clinical and translational science Issue: Volume 13:Issue 3(2020) Page Start: 482 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
4. O4–05–05: Consistency of BACE inhibitor‐mediated brain amyloid production inhibition by MK‐8931 in Alzheimer's disease patients and healthy young adults. (1st July 2013) Authors: Stone, Julie; Kleijn, Huub Jan; Dockendorf, Marissa; Ma, Lei; Palcza, John; Tseng, Jack; Tanen, Michael; Forman, Mark Journal: Alzheimer's & dementia Issue: Volume 9:Supplement 4S(2013)Part 17 Page Start: P690 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
5. P1‐038: VERUBECESTAT PHARMACOKINETIC AND EXPOSURE‐RESPONSE RESULTS FROM EPOCH: A PHASE 3 TRIAL IN MILD‐TO‐MODERATE ALZHEIMER'S DISEASE. (1st July 2006) Authors: Stone, Julie A.; Kleijn, Huub Jan; Jaworowicz, David J.; Dockendorf, Marissa; Xu, Ming; Rasmussen, Christian; Humphrey, Rebecca; Voss, Tiffini; Egan, Mike F. Journal: Alzheimer's & dementia Issue: Volume 14:Supplement 7S(2018)Part 5 Page Start: P281 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
6. P1‐044: VERUBECESTAT DISEASE PROGRESSION MODELING FROM APECS, A PHASE 3 TRIAL IN PRODROMAL ALZHEIMER'S DISEASE: NO DOSE‐ AND EXPOSURE‐DEPENDENCY IN CLINICAL ENDPOINTS. (1st July 2019) Authors: Stone, Julie A.; Kleijn, Huub Jan; Xu, Ming; Kost, James; Furtek, Christine; Mukai, Yuki; Dupre, Nicole; Voss, Tiffini; Egan, Michael F. Journal: Alzheimer's & dementia Issue: Volume 15:Supplement 7(2019)Part 4 Page Start: P249 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
7. P1‐107: Is the Peripheral Sink Hypothesis Physiologically Feasible? Evidence from Model‐Based Assessment of the Amyloid Pathway. (1st July 2016) Authors: Stone, Julie A.; Parker, Eric; Kleijn, Huub Jan; Forman, Mark; Egan, Michael; Rowland, Malcolm; Potter, William Journal: Alzheimer's & dementia Issue: Volume 12:Supplement 7S(2016)Part 9 Page Start: P443 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
8. P1–361: Improved interpretation of amyloid tracer kinetic data through model‐based analysis. (1st July 2013) Authors: Stone, Julie; Kleijn, Huub Jan; Bradstreet, Thomas E.; Drexel, Melissa; Savage, Mary; Forman, Mark; Spellman, Daniel; Laterza, Omar; Chappell, Derek; Chappell, Gloria; Tanen, Michael; Cumming, Jared; Hyde, Lynn; Kennedy, Matthew; Struyk, Arie Journal: Alzheimer's & dementia Issue: Volume 9:Supplement 4S(2013)Part 7 Page Start: P290 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
9. P2‐002: AN INTEGRATED MECHANISTIC AMYLOID PATHWAY MODEL INFORMED BY CLINICAL BIOMARKER DATA FROM VERUBECESTAT AND OTHER BACE INHIBITORS. (1st July 2019) Authors: Rasmussen, Christian; Kleijn, Huub Jan; Kalinina, Juliya; Dockendorf, Marissa; Savage, Mary J.; Struyk, Arie; Forman, Mark; Stone, Julie A. Journal: Alzheimer's & dementia Issue: Volume 15:Supplement 7(2019)Part 11 Page Start: P571 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗
10. P2‐005: Evidence from Model‐Based Assessments of Compounds Tested in Completed Clinical Trials Indicates That The Amyloid Hypothesis Has Not Been Adequately Tested. (1st July 2016) Authors: Stone, Julie A.; Kleijn, Huub Jan; Dockendorf, Marissa; Mo, Yi; Egan, Michael; Forman, Mark Journal: Alzheimer's & dementia Issue: Volume 12:Supplement 7S(2016)Part 12 Page Start: P609 Record Type: Journal Article View Content: Available online (eLD content is only available in our Reading Rooms) ↗