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You searched for: Author/Creator Hewitt, Philip G.- Hewitt, Philip G. [remove] 5
- Toxicology -- Periodicals 4
- 363.179 2
- 615.9 2
- Toxicity testing -- In vitro -- Periodicals 2
- 615.7 1
- ADR adverse drug reaction -- bcell biliary cell -- BSA bovine serum albumin -- Ccell concentration in cell lysate -- Cmax human therapeutic peak plasma concentration -- Cmed concentration in assay medium -- CV coefficient of variation -- CYP cytochrome P450 -- DME drug metabolising enzyme -- DMEM Dulbecco modified eagle medium -- DMSO dimethyl sulphoxide -- FBS foetal bovine serum -- Fin entry rate flow for one cell -- Fout exit rate flow for one cell -- HMM hepatocyte maintenance medium -- IBU ibuprofen -- ITS insulin transferrin selenium -- k1 rate constant for binding to medium proteins -- k2 rate constant for unbinding from medium proteins -- Km Michaelis–Menten constant -- LOD limit of detection -- LOQ limit of quantification -- MCMC Markov-chain Monte Carlo -- Ncell number of cells in the assay system -- NOAEC no observed adverse effect concentration -- OECD Organisation for Economic Co-operation and Development -- PHH primary human hepatocytes -- PBPK physiologically-based pharmacokinetics -- PRH primary rat hepatocytes -- Qcell total quantity in cell lysate -- Qmed total quantity in assay medium -- Qprot total quantity bound on protein -- SD standard deviation -- SW sandwich -- t1/2 half-life -- TC toxic concentration -- Tmax time to reach Cmax -- Vcell volume of a cell -- Vmax maximal metabolic rate -- Vmed volume of assay medium 1
- AMI amiodarone -- ADR adverse drug reaction -- CPZ chlorpromazine -- CsA cyclosporine A -- CYP cytochrome P450-dependent monooxygenases -- DICI Drug Induced Cholestasis Index -- DILI drug-induced liver injury -- DME drug metabolizing enzyme -- IBU ibuprofen -- NSAID non-steroidal anti-inflammatory drug -- PHH primary human hepatocytes -- PRH primary rat hepatocytes 1
- BSA bovine serum albumin -- CPZ chlorpromazine -- CYPs cytochrome P450 enzymes -- DMEM Dulbecco's modified eagle medium -- DMSO dimethyl sulfoxide -- EDTA ethylenediaminetetra acetic acid -- HPLC high pressure liquid chromatography -- ITS insulin–transferrin–selenium -- PBS phosphate buffered saline -- TC10 10% toxic concentration 1
- Biokinetics -- Ibuprofen -- In vitro -- Primary rat hepatocytes -- Primary human hepatocytes -- HepaRG cells 1
- Biokinetics -- Primary hepatocytes -- HepaRG cells -- Chlorpromazine 1