Understanding the biokinetics of ibuprofen after single and repeated treatments in rat and human in vitro liver cell systems. Issue 2 (4th March 2015)

• Record Type: Journal Article
• Authors: Truisi, Germaine L.; Consiglio, Emma Di; Parmentier, Céline; Savary, Camille C.; Pomponio, Giuliana; Bois, Frederic; Lauer, Birthe; Jossé, Rozenn; Hewitt, Philip G.; Mueller, Stefan O.; Richert, Lysiane; Guillouzo, André; Testai, Emanuela
• Is Part Of: Toxicology letters. Volume 233:Issue 2(2015)
• Page Start: 172
• Page End: 186
• Publication Date: 2015-03-04
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.01.006
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0090"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">IBU biokinetics was described in 3 <italic>in vitro</italic> systems after single and 14 day exposure.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Modelling predicted the daily kinetic behaviour along the 14 days.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Rapid uptake, a dynamic equilibrium in 1–2 days, no bioaccumulation were found.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">IBU was metabolised more efficiently in human than in rat hepatic cells as <italic>in vivo</italic>.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">The biokinetic profile could help explaining species differences and dynamics data.</p> </list-item> </list> </p> </sec> </abstract>