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Author/Creator Heath, Paul R.

1. A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. (23rd April 2015)

Authors:
Simpson, Julie E.; Ince, Paul G.; Matthews, Fiona E.; Shaw, Pamela J.; Heath, Paul R.; Brayne, Carol; Garwood, Claire; Higginbottom, Adrian; Wharton, Stephen B.; MRC Cognitive Function and Ageing Neuropathology Study Group
Journal:
Neuropathology & applied neurobiology
Issue:
Volume 41:Number 4(2015)
Page Start:
483
Record Type:
Journal Article
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3. C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. (1st February 2017)

Authors:
Stopford, Matthew J.; Higginbottom, Adrian; Hautbergue, Guillaume M.; Cooper-Knock, Johnathan; Mulcahy, Padraig J.; De Vos, Kurt J.; Renton, Alan E.; Pliner, Hannah; Calvo, Andrea; Chio, Adriano; Traynor, Bryan J.; Azzouz, Mimoun; Heath, Paul R.; Kirby, Janine; Shaw, Pamela J.
Journal:
Human molecular genetics
Issue:
Volume 26:Number 6(2017:Mar. 15)
Page Start:
1133
Record Type:
Journal Article
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4. Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia‐response and RNA processing functions. (February 2015)

Authors:
Raman, Rohini; Allen, Scott P; Goodall, Emily F; Kramer, Shelley; Ponger, Lize‐Linde; Heath, Paul R.; Milo, Marta; Hollinger, Hannah C.; Walsh, Theresa; Highley, J Robin; Olpin, Simon; McDermott, Christopher J.; Shaw, Pamela J.; Kirby, Janine
Journal:
Neuropathology & applied neurobiology
Issue:
Volume 41:Number 2(2015)
Page Start:
201
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

5. Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies. (15th February 2021)

Authors:
Waller, Rachel; Narramore, Ruth; Simpson, Julie E.; Heath, Paul R.; Verma, Nikita; Tinsley, Megan; Barnes, Jordan R.; Haris, Hanna T.; Henderson, Frances E.; Matthews, Fiona E.; Richardson, Connor D.; Brayne, Carol; Ince, Paul G.; Kalaria, Raj N.; Wharton, Stephen B.
Journal:
Brain pathology
Issue:
Volume 31:Number 3(2021)
Page Start:
n/a
Record Type:
Journal Article
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6. Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons. (15th October 2018)

Authors:
Ratcliffe, Laura E.; Vázquez Villaseñor, Irina; Jennings, Luke; Heath, Paul R.; Mortiboys, Heather; Schwartzentruber, Aurelie; Karyka, Evangelia; Simpson, Julie E.; Ince, Paul G.; Garwood, Claire J.; Wharton, Stephen B.
Journal:
Neuroscience
Issue:
Volume 390(2018)
Page Start:
46
Record Type:
Journal Article
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7. Loss of nuclear TDP‐43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones. Issue 6 (October 2014)

Authors:
Highley, J. Robin; Kirby, Janine; Jansweijer, Joeri A.; Webb, Philip S.; Hewamadduma, Channa A.; Heath, Paul R.; Higginbottom, Adrian; Raman, Rohini; Ferraiuolo, Laura; Cooper‐Knock, Johnathan; McDermott, Christopher J.; Wharton, Stephen B.; Shaw, Pamela J.; Ince, Paul G.
Journal:
Neuropathology & applied neurobiology
Issue:
Volume 40:Issue 6(2014)
Page Start:
670
Record Type:
Journal Article
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8. Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology. (7th July 2015)

Authors:
Simpson, Julie E.; Ince, Paul G.; Minett, Thais; Matthews, Fiona E.; Heath, Paul R.; Shaw, Pamela J.; Goodall, Emily; Garwood, Claire J.; Ratcliffe, Laura E.; Brayne, Carol; Rattray, Magnus; Wharton, Stephen B.
Journal:
Neuropathology & applied neurobiology
Issue:
Volume 42:Number 2(2016)
Page Start:
167
Record Type:
Journal Article
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9. Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain. (20th November 2014)

Authors:
Al‐Mashhadi, Sufana; Simpson, Julie E.; Heath, Paul R.; Dickman, Mark; Forster, Gillian; Matthews, Fiona E.; Brayne, Carol; Ince, Paul G.; Wharton, Stephen B.; Medical Research Council Cognitive Function and Ageing Study
Journal:
Brain pathology
Issue:
Volume 25:Number 5(2015:Sep.)
Page Start:
565
Record Type:
Journal Article
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