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Author/Creator Crooke, Stanley T

1. Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins. Issue 5 (30th January 2018)

Authors:
Shen, Wen; De Hoyos, Cheryl L; Sun, Hong; Vickers, Timothy A; Liang, Xue-hai; Crooke, Stanley T
Journal:
Nucleic acids research
Issue:
Volume 46:Issue 5(2018)
Page Start:
2204
Record Type:
Journal Article
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Available online (eLD content is only available in our Reading Rooms) ↗

3. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials. Issue 10057 (5th November 2016)

Authors:
Viney, Nicholas J; van Capelleveen, Julian C; Geary, Richard S; Xia, Shuting; Tami, Joseph A; Yu, Rosie Z; Marcovina, Santica M; Hughes, Steven G; Graham, Mark J; Crooke, Rosanne M; Crooke, Stanley T; Witztum, Joseph L; Stroes, Erik S; Tsimikas, Sotirios
Journal:
Lancet
Issue:
Volume 388:Issue 10057(2016)
Page Start:
2239
Record Type:
Journal Article
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5. Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides. Issue 7 (5th March 2018)

Authors:
Wang, Shiyu; Allen, Nickolas; Vickers, Timothy A; Revenko, Alexey S; Sun, Hong; Liang, Xue-hai; Crooke, Stanley T
Journal:
Nucleic acids research
Issue:
Volume 46:Issue 7(2018)
Page Start:
3579
Record Type:
Journal Article
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10. Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins. Issue 11 (29th April 2019)

Authors:
Migawa, Michael T; Shen, Wen; Wan, W Brad; Vasquez, Guillermo; Oestergaard, Michael E; Low, Audrey; De Hoyos, Cheryl L; Gupta, Ruchi; Murray, Susan; Tanowitz, Michael; Bell, Melanie; Nichols, Joshua G; Gaus, Hans; Liang, Xue-hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P
Journal:
Nucleic acids research
Issue:
Volume 47:Issue 11(2019)
Page Start:
5465
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗