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Author/Creator Chang, Sichen

11. Discovery of a novel 3, 4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 21 (1st November 2019)

Authors:
Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Gregro, Alison R.; Watson, Katherine J.; Chang, Sichen; Jenkins, Matthew T.; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 29:Issue 21(2019)
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Journal Article
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12. Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Issue 18 (15th September 2017)

Authors:
Bewley, Blake R.; Spearing, Paul K.; Weiner, Rebecca L.; Luscombe, Vincent B.; Zhan, Xiaoyan; Chang, Sichen; Cho, Hyekyung P.; Rodriguez, Alice L.; Niswender, Colleen M.; Conn, P. Jeffrey; Bridges, Thomas M.; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 18(2017)
Page Start:
4274
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Journal Article
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13. Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. (15th November 2022)

Authors:
Capstick, Rory A.; Whomble, David; Orsi, Douglas L.; Felts, Andrew S.; Rodriguez, Alice L.; Vinson, Paige N.; Chang, Sichen; Blobaum, Anna L.; Niswender, Colleen M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.; Han, Changho
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 76(2022)
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Journal Article
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14. Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists. (15th December 2022)

Authors:
Orsi, Douglas L.; Felts, Andrew S.; Rodriguez, Alice L.; Vinson, Paige N.; Cho, Hyekyung P.; Chang, Sichen; Blobaum, Anna L.; Niswender, Colleen M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.; Han, Changho
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 78(2022)
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Journal Article
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15. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2. (1st December 2021)

Authors:
Long, Madeline F.; Capstick, Rory A.; Spearing, Paul K.; Engers, Julie L.; Gregro, Alison R.; Bollinger, Sean R.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Cho, Hyekyung P.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.; Engers, Darren W.; Temple,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 53(2021)
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Record Type:
Journal Article
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16. Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes. Issue 4 (15th February 2020)

Authors:
Temple, Kayla J.; Long, Madeline F.; Engers, Julie L.; Watson, Katherine J.; Chang, Sichen; Luscombe, Vincent B.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 4(2020)
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Journal Article
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17. Evaluation of 1, 2, 3‐Triazoles as Amide Bioisosteres In Cystic Fibrosis Transmembrane Conductance Regulator Modulators VX‐770 and VX‐809. Issue 14 (11th February 2019)

Authors:
Doiron, Jake E.; Le, Christina A.; Ody, Britton K.; Brace, Jonathon B.; Post, Savannah J.; Thacker, Nathan L.; Hill, Harrison M.; Breton, Gary W.; Mulder, Matthew J.; Chang, Sichen; Bridges, Thomas M.; Tang, Liping; Wang, Wei; Rowe, Steven M.; Aller, Stephen G.; Turlington, Mark
Journal:
Chemistry
Issue:
Volume 25:Issue 14(2019)
Page Start:
3662
Record Type:
Journal Article
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18. Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Issue 15 (1st August 2016)

Authors:
Panarese, Joseph D.; Cho, Hykeyung P.; Adams, Jeffrey J.; Nance, Kellie D.; Garcia-Barrantes, Pedro M.; Chang, Sichen; Morrison, Ryan D.; Blobaum, Anna L.; Niswender, Colleen M.; Stauffer, Shaun R.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 15(2016)
Page Start:
3822
Record Type:
Journal Article
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19. Lead optimization of the VU0486321 series of mGlu1 PAMs. Part 4: SAR reveals positive cooperativity across multiple mGlu receptor subtypes leading to subtype unselective PAMs. (15th January 2021)

Authors:
Davis, Dexter C.; Bungard, Joseph D.; Chang, Sichen; Rodriguez, Alice L.; Blobaum, Annie L.; Boutaud, Olivier; Melancon, Bruce J.; Niswender, Colleen M.; Jeffrey Conn, P.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 32(2021)
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Journal Article
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20. Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology. Issue 11 (1st June 2017)

Authors:
Melancon, Bruce J.; Wood, Michael R.; Noetzel, Meredith J.; Nance, Kellie D.; Engelberg, Eileen M.; Han, Changho; Lamsal, Atin; Chang, Sichen; Cho, Hyekyung P.; Byers, Frank W.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Wu, Dedong; Brandon, Nic...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 11(2017)
Page Start:
2296
Record Type:
Journal Article
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