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Author/Creator Chang, Sichen

1. Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs. Issue 2 (15th January 2017)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B.; Weiner, Rebecca L.; Cho, Hyekyung P.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Brandon, Nicho...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 2(2017)
Page Start:
171
Record Type:
Journal Article
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2. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides. Issue 23 (1st December 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 23(2017)
Page Start:
5179
Record Type:
Journal Article
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3. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Issue 13 (1st July 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Bertron, Jeanette L.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E.; Conn, P. Jeffrey...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 13(2017)
Page Start:
2990
Record Type:
Journal Article
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4. Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]. Issue 17 (15th September 2018)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 28:Issue 17(2018)
Page Start:
3014
Record Type:
Journal Article
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5. Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro. (15th October 2022)

Authors:
Reed, Carson W.; Rodriguez, Alice L.; Kalbfleisch, Jacob J.; Seto, Mabel; Jenkins, Matthew T.; Blobaum, Anna L.; Chang, Sichen; Lindsley, Craig W.; Niswender, Colleen M.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 74(2022)
Page Start:
Record Type:
Journal Article
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6. Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Issue 15 (1st August 2017)

Authors:
Bender, Aaron M.; Weiner, Rebecca L.; Luscombe, Vincent B.; Ajmera, Sonia; Cho, Hyekyung P.; Chang, Sichen; Zhan, Xiaoyan; Rodriguez, Alice L.; Niswender, Colleen M.; Engers, Darren W.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 15(2017)
Page Start:
3576
Record Type:
Journal Article
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7. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl)thieno[2, 3-d]pyrimidine core. Issue 13 (1st July 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Engers, Julie L.; Bollinger, Katrina A.; Melancon, Bruce J.; Tarr, James C.; Han, Changho; West, Mary; Gregro, Alison R.; Lamsal, Atin; Chang, Sichen; Ajmera, Sonia; Smith, Emery; Chase, Peter; Hodder, Peter S.; Bubser, Michael; Jones, Carrie K.; Hopkins, C...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 13(2016)
Page Start:
3029
Record Type:
Journal Article
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8. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Issue 17 (1st September 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Tarr, James C.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Foster, Jarrett J.; Smith, Emery; Chase, Peter; Hodder, Peter S.; Engers, Darren W.; Niswender, Colleen M.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 17(2016)
Page Start:
4282
Record Type:
Journal Article
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9. Discovery of a novel 2, 3-dimethylimidazo[1, 2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype. Issue 3 (1st February 2020)

Authors:
Temple, Kayla J.; Engers, Julie L.; Long, Madeline F.; Watson, Katherine J.; Chang, Sichen; Luscombe, Vincent B.; Jenkins, Matthew T.; Rodriguez, Alice L.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 30:Issue 3(2020)
Page Start:
Record Type:
Journal Article
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10. Discovery of a novel 2, 4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 22 (15th November 2017)

Authors:
Long, Madeline F.; Engers, Julie L.; Chang, Sichen; Zhan, Xiaoyan; Weiner, Rebecca L.; Luscombe, Vincent B.; Rodriguez, Alice L.; Cho, Hyekyung P.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 22(2017)
Page Start:
4999
Record Type:
Journal Article
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