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Date 2017 Author/Creator Bridges, Thomas M.

1. Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs. Issue 2 (15th January 2017)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B.; Weiner, Rebecca L.; Cho, Hyekyung P.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Brandon, Nicho...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 2(2017)
Page Start:
171
Record Type:
Journal Article
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2. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides. Issue 23 (1st December 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 23(2017)
Page Start:
5179
Record Type:
Journal Article
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3. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Issue 13 (1st July 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Bertron, Jeanette L.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E.; Conn, P. Jeffrey...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 13(2017)
Page Start:
2990
Record Type:
Journal Article
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4. Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Issue 6 (15th March 2017)

Authors:
McGowan, Kevin M.; Nance, Kellie D.; Cho, Hykeyung P.; Bridges, Thomas M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 6(2017)
Page Start:
1356
Record Type:
Journal Article
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5. Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Issue 15 (1st August 2017)

Authors:
Bender, Aaron M.; Weiner, Rebecca L.; Luscombe, Vincent B.; Ajmera, Sonia; Cho, Hyekyung P.; Chang, Sichen; Zhan, Xiaoyan; Rodriguez, Alice L.; Niswender, Colleen M.; Engers, Darren W.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 15(2017)
Page Start:
3576
Record Type:
Journal Article
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6. Discovery of a novel 2, 4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Issue 22 (15th November 2017)

Authors:
Long, Madeline F.; Engers, Julie L.; Chang, Sichen; Zhan, Xiaoyan; Weiner, Rebecca L.; Luscombe, Vincent B.; Rodriguez, Alice L.; Cho, Hyekyung P.; Niswender, Colleen M.; Bridges, Thomas M.; Conn, P. Jeffrey; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 22(2017)
Page Start:
4999
Record Type:
Journal Article
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7. Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Issue 18 (15th September 2017)

Authors:
Bewley, Blake R.; Spearing, Paul K.; Weiner, Rebecca L.; Luscombe, Vincent B.; Zhan, Xiaoyan; Chang, Sichen; Cho, Hyekyung P.; Rodriguez, Alice L.; Niswender, Colleen M.; Conn, P. Jeffrey; Bridges, Thomas M.; Engers, Darren W.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 18(2017)
Page Start:
4274
Record Type:
Journal Article
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8. Optimization of M4 positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology. Issue 11 (1st June 2017)

Authors:
Melancon, Bruce J.; Wood, Michael R.; Noetzel, Meredith J.; Nance, Kellie D.; Engelberg, Eileen M.; Han, Changho; Lamsal, Atin; Chang, Sichen; Cho, Hyekyung P.; Byers, Frank W.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Wu, Dedong; Brandon, Nic...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 11(2017)
Page Start:
2296
Record Type:
Journal Article
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9. Synthesis and evaluation of 4, 6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype. Issue 11 (1st June 2017)

Authors:
Bender, Aaron M.; Weiner, Rebecca L.; Luscombe, Vincent B.; Cho, Hyekyung P.; Niswender, Colleen M.; Engers, Darren W.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 11(2017)
Page Start:
2479
Record Type:
Journal Article
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