Search

Author/Creator Bridges, Thomas M.

1. Acyl dihydropyrazolo[1, 5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators. Issue 22 (15th November 2015)

Authors:
Malosh, Chrysa; Turlington, Mark; Bridges, Thomas M.; Rook, Jerri M.; Noetzel, Meredith J.; Vinson, Paige N.; Steckler, Thomas; Lavreysen, Hilde; Mackie, Claire; Bartolomé-Nebreda, José M.; Conde-Ceide, Susana; Martínez-Viturro, Carlos M.; Piedrafita, María; Sánchez-Casado, M. Rosa; Macdonald, Gr...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 25:Issue 22(2015)
Page Start:
5115
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

2. Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs. Issue 2 (15th January 2017)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Poslusney, Michael S.; Melancon, Bruce J.; Tarr, James C.; Lamsal, Atin; Chang, Sichen; Luscombe, Vincent B.; Weiner, Rebecca L.; Cho, Hyekyung P.; Bubser, Michael; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Engers, Darren W.; Brandon, Nicho...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 2(2017)
Page Start:
171
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

3. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides. Issue 23 (1st December 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 23(2017)
Page Start:
5179
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

4. Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Issue 13 (1st July 2017)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Bertron, Jeanette L.; Weiner, Rebecca L.; Rodriguez, Alice L.; Lamsal, Atin; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E.; Conn, P. Jeffrey...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 13(2017)
Page Start:
2990
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

5. Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154. (January 2018)

Authors:
Gould, Robert W.; Grannan, Michael D.; Gunter, Barak W.; Ball, Jacob; Bubser, Michael; Bridges, Thomas M.; Wess, Jurgen; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E.; Niswender, Colleen M.; Lindsley, Craig W.; Conn, P. Jeffrey; Jones, Carrie K.
Journal:
Neuropharmacology
Issue:
Volume 128(2018)
Page Start:
492
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

6. Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Issue 6 (15th March 2017)

Authors:
McGowan, Kevin M.; Nance, Kellie D.; Cho, Hykeyung P.; Bridges, Thomas M.; Conn, P. Jeffrey; Jones, Carrie K.; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 6(2017)
Page Start:
1356
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

7. Corrigendum to "Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides" [Bioorg. Med. Chem. Lett. 27(23) (2017) 5179–5184]. Issue 17 (15th September 2018)

Authors:
Tarr, James C.; Wood, Michael R.; Noetzel, Meredith J.; Melancon, Bruce J.; Lamsal, Atin; Luscombe, Vincent B.; Rodriguez, Alice L.; Byers, Frank W.; Chang, Sichen; Cho, Hyekyung P.; Engers, Darren W.; Jones, Carrie K.; Niswender, Colleen M.; Wood, Michael W.; Brandon, Nicholas J.; Duggan, Mark E...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 28:Issue 17(2018)
Page Start:
3014
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

8. Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Issue 15 (1st August 2017)

Authors:
Bender, Aaron M.; Weiner, Rebecca L.; Luscombe, Vincent B.; Ajmera, Sonia; Cho, Hyekyung P.; Chang, Sichen; Zhan, Xiaoyan; Rodriguez, Alice L.; Niswender, Colleen M.; Engers, Darren W.; Bridges, Thomas M.; Conn, P. Jeffrey; Lindsley, Craig W.
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 27:Issue 15(2017)
Page Start:
3576
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

9. Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5, 6-dimethyl-4-(piperidin-1-yl)thieno[2, 3-d]pyrimidine core. Issue 13 (1st July 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Engers, Julie L.; Bollinger, Katrina A.; Melancon, Bruce J.; Tarr, James C.; Han, Changho; West, Mary; Gregro, Alison R.; Lamsal, Atin; Chang, Sichen; Ajmera, Sonia; Smith, Emery; Chase, Peter; Hodder, Peter S.; Bubser, Michael; Jones, Carrie K.; Hopkins, C...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 13(2016)
Page Start:
3029
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗

10. Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Issue 17 (1st September 2016)

Authors:
Wood, Michael R.; Noetzel, Meredith J.; Tarr, James C.; Rodriguez, Alice L.; Lamsal, Atin; Chang, Sichen; Foster, Jarrett J.; Smith, Emery; Chase, Peter; Hodder, Peter S.; Engers, Darren W.; Niswender, Colleen M.; Brandon, Nicholas J.; Wood, Michael W.; Duggan, Mark E.; Conn, P. Jeffrey; Bridges,...
Journal:
Bioorganic & medicinal chemistry letters
Issue:
Volume 26:Issue 17(2016)
Page Start:
4282
Record Type:
Journal Article
View Content:
Available online (eLD content is only available in our Reading Rooms) ↗