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- A-CM astrocyte derived-conditioned medium -- BME Basal Medium Eagle -- Bz-ATP 3′-O-benzoyl-benzoyl-ATP -- CGNs cerebellar granule neurons -- CNS central nervous system -- CSF cerebrospinal fluid -- JNK c-Jun N-terminal kinase -- DTT dithiothreitol -- ELISA enzyme linked immunosorbent assay -- EVs extracellular vesicles -- FBS fetal bovine serum -- GFAP glial fibrillary acidic protein -- GUA guanine -- GUO guanosine -- IL-1β interleukin-1β -- LAMP-1 Lysosome-Associated Membrane Protein-1 -- LPS lipopolysaccharide -- LDH lactate dehydrogenase -- MAPK mitogen-activated protein kinase -- M-CM microglia derived-conditioned medium -- N-CM neuron derived-conditioned medium -- PBS phosphate buffered saline -- PF pellet fraction -- PNP purine nucleoside phosphorylase -- P2X7R P2X7 receptor -- RT room temperature -- SDS sodium dodecyl sulphate -- SF soluble fraction -- VAMP7 Vesicle-associated membrane protein 7 -- XOR xanthine oxidoreductase 1