The absence of genotoxicity of Aloe vera beverages: A review of the literature. (April 2023)

• Record Type: Journal Article
• Authors: Kim, Sang-Tae; Pressman, Peter; Clemens, Roger; Moore, Allison; Hamilton, Ryan; Hayes, A. Wallace
• Is Part Of: Food and chemical toxicology. Volume 174(2023)
• Publication Date: 2023-04
• Subjects: Aloe vera -- Aloe barbadensis Miller -- Inner leaf extract -- Decolorized -- HADs -- Aloin; Toxicology -- Periodicals; Food poisoning -- Periodicals; Food Poisoning -- Periodicals; Toxicology -- Periodicals; Toxicologie -- Périodiques; Intoxications alimentaires -- Périodiques; Food poisoning; Toxicology; Periodicals; Electronic journals; 615.9
• DOI: 10.1016/j.fct.2023.113628
• Languages: English
• ISSNs: 0278-6915

Abstract

Abstract: Aloe has a long history of topical and systemic use with testimonials of countless health benefits and is one of the most popular botanical medicines in the world for the management of a wide variety both of benign and serious ailments including irritable bowel syndromes, osteoarthritis, Type II diabetes mellitus, and viral respiratory illness. The human consumption of Aloe vera extract in beverage form has substantially grown over the last several decades, in no small part, due to the increased consumer interest in alternative approaches to health benefits. The principal aim of the present paper is to characterize the research to date that has explored the genotoxic potential of Aloe vera inner leaf gel extract and decolorized whole leaf extract used in commercially available food-grade drinkable products which contain no more than 10 ppm aloin. Despite prevailing public health opinion, especially in Europe, the consensus of the reviewed studies retrieved from the peer-reviewed literature together with a mutagenic evaluation of an Aloe vera whole leaf decolorized spray-dried powder is that these products are not genotoxic. Highlights: Long history of use with testimonials of countless health benefits. Popular botanical for management of both of benign and serious ailments including irritable bowel syndromes, osteoarthritis, Type II diabetes mellitus, and viral respiratory illness. Characterize genotoxic potential of inner leaf gel extract and decolorized whole leaf extract used in food-grade drinkable products which contain no more than 10 ppm aloin. Neither is genotoxic.