An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. Issue 3 (21st March 2023)

• Record Type: Journal Article
• Authors: Koskela, Kirsi; Sauni, Riitta; Uitti, Jukka; Oksa, Panu; Moilanen, Eeva; Hämäläinen, Mari; Lehtimäki, Lauri
• Is Part Of: Journal of occupational and environmental medicine. Volume 65:Issue 3(2023)
• Page Start: 203
• Page End: 209
• Publication Date: 2023-03-21
• Subjects: markers of inflammation -- adipokines -- adipsin -- lung inflammation -- occupational exposure -- complement system; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000002736
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Foundry work is a known risk factor for airway inflammation and chronic obstructive pulmonary disease. In this follow-up study, we show that an increase in the plasma level of adipsin is associated with higher dust exposure and the development of airway obstruction in foundry workers. Abstract : Objective: The aim of the study was to assess whether plasma adipokine levels (adipsin, adiponectin, leptin, and resistin) are associated with pulmonary function in foundry workers. Methods: We examined 65 dust-exposed foundry workers and 40 nonexposed controls and analyzed their lung function and plasma adipokine levels at baseline and after approximately 7 years of follow-up. Results: A higher increase in plasma adipsin was associated with the development of airway obstruction in exposed subjects during follow-up after adjusting for body mass index changes during the follow-up period. Furthermore, the increase in adipsin levels was positively associated with cumulative dust exposure even after adjusting for smoking and body mass index changes during follow-up ( P = 0.015). Conclusion: The results suggest that plasma adipsin is involved in the pathogenesis of subclinical airway inflammation and the development of chronic obstruction and is induced by occupational dust exposure.