Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer. Issue 1 (14th February 2023)

• Record Type: Journal Article
• Authors: Liao, Caizhi; Wu, Zhihao; Lin, Chan; Chen, Xiaofeng; Zou, Yaqun; Zhao, Wan; Li, Xin; Huang, Guangqi; Xu, Baisheng; Briganti, Giovanni E.; Qi, Yan; Wang, Xianshu; Zeng, Tao; Wuethrich, Alain; Zou, Hongzhi
• Is Part Of: SMART MEDICINE. Volume 2:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-02-14
• Subjects: nano diagnostics -- nanomaterial -- prostate cancer (PCa) -- urinary biomarker -- urinary liquid biopsy
• DOI: 10.1002/SMMD.20220020
• Languages: English
• ISSNs: 2751-1871

Abstract

Abstract: Prostate cancer remains the second‐most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate‐specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, resulting in a high rate of overdiagnosis and underdiagnosis. Thus, the development of novel biomarkers for prostate cancer detection remains an intriguing challenge. Urine is emerging as a source for prostate cancer biomarker discovery. Currently, new urine biomarkers already outperform serum PSA in clinical diagnosis. Meanwhile, the advances in nanotechnology have provided a suite of diagnostic tools to study prostate cancer in more detail, sparking a new era of biomarker discoveries. In this review, we envision that future prostate cancer diagnosis will probably integrate multiplex nano‐diagnostic approaches to detect novel urinary biomarkers. However, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome. Abstract : For prostate cancer diagnosis, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome. The future prostate cancer diagnosis will probably integrate multiplex nano diagnostic approaches to detect novel urinary biomarkers.