Electroencephalography of mechanically ventilated patients at high risk of delirium. (5th May 2021)

• Record Type: Journal Article
• Authors: Eskioglou, Elissavet; Iaquaniello, Carolina; Alvarez, Vincent; Rüegg, Stephan; Schindler, Kaspar; Rossetti, Andrea O.; Oddo, Mauro
• Is Part Of: Acta neurologica Scandinavica. Volume 144:Number 3(2021)
• Page Start: 296
• Page End: 302
• Publication Date: 2021-05-05
• Subjects: critical care -- delirium -- EEG; Neurology -- Periodicals; 616.8
• DOI: 10.1111/ane.13447
• Languages: English
• ISSNs: 0001-6314

Abstract

Abstract: Objective: Neurophysiological exploration of ICU delirium is limited. Here, we examined EEG characteristics of medical‐surgical critically ill patients with new‐onset altered consciousness state at high risk for ICU delirium. Materials and methods: Pre‐planned analysis of non‐neurological mechanically ventilated medical‐surgical ICU subjects, who underwent a prospective multicenter randomized, controlled EEG study (NCT03129438, April 2017–November 2018). EEG characteristics, according to the 2012 ACNS nomenclature, included background activity, rhythmic periodic patterns/epileptic activity, amplitude, frequency, stimulus‐induced discharges, triphasic waves, reactivity, and NREM sleep. We explored EEG findings in delirious versus non‐delirious patients, specifically focusing on the presence of burst‐suppression and rhythmic periodic patterns (ictal‐interictal continuum), and ictal activity. Results: We analyzed 91 patients (median age, 66 years) who underwent EEG because of new‐onset altered consciousness state at a median 5 days from admission; 42 patients developed delirium (46%). Burst‐suppression (10 vs 0%, p = .02), rhythmic/periodic patterns (43% vs 22%, p = .03) and epileptiform activity (7 vs 0%, p = .05) were more frequent in delirious versus non‐delirious patients. The presence of at least one of these abnormal EEG findings (32/91 patients; 35%) was associated with a significant increase in the likelihood of delirium (42 vs 15%, p = .006). Cumulative dose of sedatives and analgesics, as well as all other EEG characteristics, did not differ significantly between the two groups. Conclusion: In mechanically ventilated non‐neurological critically ill patients with new‐onset alteration of consciousness, EEG showing burst‐suppression, rhythmic or periodic patterns, or seizures/status epilepticus indicate an increased risk of ICU delirium.