Models of Inflammation: Carrageenan Air Pouch. Issue 8 (9th August 2021)

• Record Type: Journal Article
• Authors: Fehrenbacher, Jill C.; McCarson, Kenneth E.
• Is Part Of: Current protocols. Volume 1:Issue 8(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-09
• Subjects: air pouch -- animal model -- carrageenan -- edema -- inflammation -- inflammatory mediator -- oxidative stress -- PGE2 -- TNF alpha; Life sciences -- Laboratory manuals -- Periodicals; Biology -- Laboratory manuals -- Periodicals; Life sciences -- Technique -- Periodicals; Biology -- Technique -- Periodicals; 570.028
• DOI: 10.1002/cpz1.183
• Languages: English
• ISSNs: 2691-1299

Abstract

Abstract: The subcutaneous air pouch is an in vivo model that can be used to study the components of acute and chronic inflammation, the resolution of the inflammatory response, the oxidative stress response, and potential therapeutic targets for treating inflammation. Injection of irritants into an air pouch in rats or mice induces an inflammatory response that can be quantified by the volume of exudate produced, the infiltration of cells, and the release of inflammatory mediators. The model presented in this article has been extensively used to identify potential anti‐inflammatory drugs. © 2021 Wiley Periodicals LLC. Basic Protocol : Air pouch model in the rat Alternate Protocol : Air pouch model in the mouse