Microfluidics: Stochastic and Age‐Dependent Proteostasis Decline Underlies Heterogeneity in Heat‐Shock Response Dynamics (Small 30/2021). Issue 30 (28th July 2021)

• Record Type: Journal Article
• Authors: Vertti‐Quintero, Nadia; Berger, Simon; Casadevall i Solvas, Xavier; Statzer, Cyril; Annis, Jillian; Ruppen, Peter; Stavrakis, Stavros; Ewald, Collin Y.; Gunawan, Rudiyanto; deMello, Andrew J.
• Is Part Of: Small. Volume 17:Issue 30(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-07-28
• Subjects: aging -- C. elegans -- heat‐shock response -- heterogeneity -- microfluidics -- proteostasis; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202170157
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number 2102145, Collin Y. Ewald, Rudiyanto Gunawan, and co‐workers highlight a microfluidic device used for sorting adult C. elegans populations—in a high‐throughput manner—based on individual GFP expression. The heterogeneous dynamic heat‐shock response, its relation to proteostasis, and how it can predict lifespan are thoroughly studied. Image credit: Mrs. Yujia Ma.