Wireless Localized Electrical Stimulation Generated by an Ultrasound‐Driven Piezoelectric Discharge Regulates Proinflammatory Macrophage Polarization. Issue 13 (3rd May 2021)

• Record Type: Journal Article
• Authors: Kong, Ying; Liu, Feng; Ma, Baojin; Duan, Jiazhi; Yuan, Wenhu; Sang, Yuanhua; Han, Lin; Wang, Shuhua; Liu, Hong
• Is Part Of: Advanced science. Volume 8:Issue 13(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-03
• Subjects: electrical stimulation -- macrophage polarization -- piezoelectric materials -- proinflammatory -- ultrasound; Science -- Periodicals; 505
• DOI: 10.1002/advs.202100962
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Proinflammatory (M1) macrophages play a vital role in antitumor immunity, and regulation of proinflammatory macrophage polarization is critical for immunotherapy. The polarization of macrophages can be regulated by biological or chemical stimulation, but investigations of the regulatory effect of physical stimulation are limited. Herein, regulating macrophage polarization with localized electrical signals derived from a piezoelectric β ‐phase poly(vinylidene fluoride) ( β ‐PVDF) film in a wireless mode is proposed. Charges released on the surface of the β ‐PVDF film driven by ultrasonic irradiation can significantly enhance the M1 polarization of macrophages. Mechanistic investigation confirms that electrical potentials rather than reactive oxygen species and mechanical forces enable Ca 2+ influx through voltage‐gated channels and establishment of the Ca 2+ ‐CAMK2A‐NF‐ κ B axis to promote the proinflammatory macrophage response during ultrasound treatment. Piezoelectric material‐mediated electrical signal‐activated proinflammatory macrophages significantly inhibit tumor cell proliferation. A method for electrogenetic regulation of immune cells as well as a powerful tool for engineering macrophages for immunotherapy is provided here. Abstract : Regulating macrophage polarization with localized electrical signals derived from a piezoelectric β ‐phase poly(vinylidene fluoride) ( β ‐PVDF) film in a wireless mode is proposed, providing a method for electrogenetic regulation of immune cells as well as a powerful tool for engineering macrophages for immunotherapy.