Noninvasive quantification of cerebrovascular pressure changes using 4D Flow MRI. Issue 6 (25th August 2021)

• Record Type: Journal Article
• Authors: Marlevi, David; Schollenberger, Jonas; Aristova, Maria; Ferdian, Edward; Ma, Yue; Young, Alistair A.; Edelman, Elazer R.; Schnell, Susanne; Figueroa, C. Alberto; Nordsletten, David A.
• Is Part Of: Magnetic resonance in medicine. Volume 86:Issue 6(2021)
• Page Start: 3096
• Page End: 3110
• Publication Date: 2021-08-25
• Subjects: 4D Flow MRI -- cerebrovascular -- hemodynamics -- patient‐specific modeling -- relative pressure; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.28928
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: Hemodynamic alterations are indicative of cerebrovascular disease. However, the narrow and tortuous cerebrovasculature complicates image‐based assessment, especially when quantifying relative pressure. Here, we present a systematic evaluation of image‐based cerebrovascular relative pressure mapping, investigating the accuracy of the routinely used reduced Bernoulli (RB), the extended unsteady Bernoulli (UB), and the full‐field virtual work‐energy relative pressure ( ν WERP) method. Methods: Patient‐specific in silico models were used to generate synthetic cerebrovascular 4D Flow MRI, with RB, UB, and ν WERP performance quantified as a function of spatiotemporal sampling and image noise. Cerebrovascular relative pressures were also derived in 4D Flow MRI from healthy volunteers ( n = 8 ), acquired at two spatial resolutions ( dx = 1.1 and 0.8 mm). Results: The in silico analysis indicate that accurate relative pressure estimations are inherently coupled to spatial sampling: at dx = 1.0 mm high errors are reported for all methods; at dx = 0.5 mm ν WERP recovers relative pressures at a mean error of 0.02 ± 0.25 mm Hg, while errors remain higher for RB and UB (mean error of −2.18 ± 1.91 and −2.18 ± 1.87 mm Hg, respectively). The dependence on spatial sampling is also indicated in vivo, albeit with higher correlative dependence between resolutions using ν WERP ( k = 0.64, R 2 = 0.81 for dx = 1.1 vs. 0.8 mm) than with RB or UB ( k = 0.04, R 2 = 0.03, and k = 0.07, R 2 = 0.07, respectively). Conclusion: Image‐based full‐field methods such as ν WERP enable cerebrovascular relative pressure mapping; however, accuracy is directly dependent on utilized spatial resolution.