Anti‐Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis. Issue 2 (26th December 2021)

• Record Type: Journal Article
• Authors: Pinal‐Fernandez, Iago; Pak, Katherine; Gil‐Vila, Albert; Baucells, Andres; Plotz, Benjamin; Casal‐Dominguez, Maria; Derfoul, Assia; Martinez‐Carretero, Maria Angeles; Selva‐O'Callaghan, Albert; Sabbagh, Sara; Casciola‐Rosen, Livia; Albayda, Jemima; Paik, Julie; Tiniakou, Eleni; Danoff, Sonye K.; Lloyd, Thomas E.; Miller, Frederick W.; Rider, Lisa G.; Christopher‐Stine, Lisa; Mammen, Andrew L.
• Other Names: Schmeling Heinrike investigator.; Arabshahi Bita investigator.; Balboni Imelda investigator.; Ballinger Susan investigator.; Barillas‐Arias Lilliana investigator.; Becker Mara investigator.; Bingham Catherine April investigator.; Bohnsack John F. investigator.; Carrasco Ruy investigator.; Cartwright Victoria investigator.; Cawkwell Gail D. investigator.; Curiel Rodolfo investigator.; Dare Jason investigator.; DeGuzman Marietta M. investigator.; Eade Kaleo investigator.; Ebernardt Barbara Anne investigator.; Edelheit Barbara S. investigator.; El‐Hallak Moussa investigator.; Finkel Terri H. investigator.; George Stephen W. investigator.; Goldmuntz Ellen A. investigator.; Gottlieb Beth investigator.; Graham Brent investigator.; Hannan William investigator.; Henrickson Michael investigator.; Higgins Gloria C. investigator.; Hobday Patricia investigator.; Hoftman Alice investigator.; Hong Sandy investigator.; Huber Adam investigator.; Imundo Lisa investigator.; Inman Christi investigator.; Jansen Anna investigator.; Jarvis James investigator.; Jung Lawrence investigator.; Kahn Philip investigator.; Katona Ildy M. investigator.; Kimura Yukiko investigator.; Kingsbury Daniel J. investigator.; Knibbe W Patrick investigator.; Lang Bianca A. investigator.; Leffler Maureen investigator.; Lerman Melissa investigator.; Lindsley Carol B. investigator.; Madson Katherine L. investigator.; Mamyrova Gulnara investigator.; Milojevic Diana investigator.; Mitchell Stephen R. investigator.; Modica Renee investigator.; Myers Linda investigator.; Nanda Kabita investigator.; Nativ Simona investigator.; O'Hanlon Terrance investigator.; Olson Judyann C. investigator.; Pachman Lauren M. investigator.; Passo Murray H. investigator.; Perez Maria D. investigator.; Person Donald A. investigator.; Punaro Marilyn G. investigator.; Ray Linda I. investigator.; Rennebohm Robert M. investigator.; Rivas‐Chacon Rafael F. investigator.; Ronis Tova investigator.; Rosenkranz Margalit investigator.; Rothman Deborah investigator.; Schiffenbauer Adam investigator.; Shaham Bracha investigator.; Shenoi Susan investigator.; Sherry David investigator.; Siegel David investigator.; Smukler Abigail investigator.; Soep Jennifer investigator.; Stoll Matthew investigator.; Sule Sangeeta H. investigator.; Sundel Robert investigator.; Tarvin Stacey investigator.; Tesher Melissa investigator.; Vogelgesang Scott A. investigator.; Volochayev Rita investigator.; Wahezi Dawn investigator.; Wargula Jennifer C. investigator.; Weiser Peter investigator.; Weiss Pamela investigator.; White Patience H. investigator.; Zeft Andrew investigator.; Zemel Lawrence S. investigator.; Zhao Yongdong investigator.;
• Is Part Of: Arthritis & rheumatology. Volume 74:Issue 2(2022)
• Page Start: 358
• Page End: 364
• Publication Date: 2021-12-26
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.41931
• Languages: English
• ISSNs: 2326-5191

Abstract

Abstract : Objective: To define the prevalence and clinical phenotype of anti‐cortactin autoantibodies in adult and juvenile myositis. Methods: In this longitudinal cohort study, anti‐cortactin autoantibody titers were assessed by enzyme‐linked immunosorbent assay in 670 adult myositis patients and 343 juvenile myositis patients as well as in 202 adult healthy controls and 90 juvenile healthy controls. The prevalence of anti‐cortactin autoantibodies was compared among groups. Clinical features of patients with and those without anti‐cortactin autoantibodies were also compared. Results: Anti‐cortactin autoantibodies were more common in adult dermatomyositis (DM) patients (15%; P = 0.005), particularly those with coexisting anti–Mi‐2 autoantibodies (24%; P = 0.03) or anti–NXP‐2 autoantibodies (23%; P = 0.04). In adult myositis, anti‐cortactin was associated with DM skin involvement (62% of patients with anti‐cortactin versus 38% of patients without anti‐cortactin; P = 0.03), dysphagia (36% versus 17%; P = 0.02) and coexisting anti–Ro 52 autoantibodies (47% versus 26%; P = 0.001) or anti‐NT5c1a autoantibodies (59% versus 33%; P = 0.001). Moreover, the titers of anti‐cortactin antibodies were higher in patients with interstitial lung disease (0.15 versus 0.12 arbitrary units; P = 0.03). The prevalence of anti‐cortactin autoantibodies was not different in juvenile myositis patients (2%) or in any juvenile myositis subgroup compared to juvenile healthy controls (4%). Nonetheless, juvenile myositis patients with these autoantibodies had a higher prevalence of "mechanic's hands" (25% versus 7%; P = 0.03), a higher number of hospitalizations (2.9 versus 1.3; P = 0.04), and lower peak creatine kinase values (368 versus 818 IU/liter; P = 0.02) than those without anti‐cortactin. Conclusion: The prevalence of anti‐cortactin autoantibodies is increased in adult DM patients with coexisting anti–Mi‐2 or anti–NXP‐2 autoantibodies. In adults, anti‐cortactin autoantibodies are associated with dysphagia and interstitial lung disease.