Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression. Issue 16 (20th July 2021)

• Record Type: Journal Article
• Authors: Xu, Ruidan; Yang, Yongfeng; Zheng, Xiaofeng
• Is Part Of: FEBS letters. Volume 595:Issue 16(2021)
• Page Start: 2071
• Page End: 2084
• Publication Date: 2021-07-20
• Subjects: adenylate kinase -- ATPase -- breast cancer -- Cajal bodies -- colorectal cancer -- DNA damage response -- genome stability -- immunity dysfunction -- leukemia -- signaling pathway regulation; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.14158
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Human coilin‐interacting nuclear ATPase protein (hCINAP), also known as adenylate kinase 6 (AK6), is an atypical adenylate kinase with critical roles in many biological processes, including gene transcription, ribosome synthesis, cell metabolism, cell proliferation and apoptosis, DNA damage responses, and genome stability. Furthermore, hCINAP/AK6 dysfunction is associated with cancer and various inflammatory diseases. In this review, we summarize the structural features and biological roles of hCINAP in several important signaling pathways, as well as its connection with tumor onset and progression. Abstract :