Biomarkers of human papillomavirus (HPV)‐driven head and neck cancer in Latin America and Europe study: Study design and HPV DNA/p16INK4a status. Issue 1 (2nd November 2021)

• Record Type: Journal Article
• Authors: Sichero, Laura; Tagliabue, Marta; Mota, Giana; Ferreira, Silvaneide; Nunes, Rafaella A. L.; Castañeda, Carlos Arturo; Castillo, Miluska; Correa, Rita Mariel; Perdomo, Sandra; Rodríguez‐Urrego, Paula A.; Matos, Leandro Luongo; Mohssen, Ansarin; Gheit, Tarik; Tommasino, Massimo; Chiocca, Susanna; Villa, Luisa Lina
• Is Part Of: Head & neck. Volume 44:Issue 1(2022)
• Page Start: 122
• Page End: 133
• Publication Date: 2021-11-02
• Subjects: head and neck cancer -- human papillomavirus -- multinational study -- prevalence -- risk factors; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.26912
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Human papillomavirus (HPV)‐driven head/neck squamous cell carcinomas (HNSCC) prevalence varies globally. We evaluated HPV DNA and p16 INK4a in formalin fixed paraffin embedded (FFPE) HNSCC from Argentina, Brazil, Colombia, and Peru. Methods: HPV was genotyped by PCR‐hybridization. All HPV DNA positive and some HPV DNA negative cases underwent p16 INK4a immunohistochemistry. Results: HPV DNA was detected in 32.8%, 11.1%, and 17.8% of oropharyngeal (OPC), oral cavity (OCC) and laryngeal (LC) cancers, respectively. OPC HPV prevalence was higher in Colombia (94.7%), and Argentina (42.6%) compared to Brazil (10.6%) and Peru (0.0%). HPV‐16 was the most detected. Other HPVs were found in LC. Higher rates of p16 INK4a positivity were observed among HPV positive OPC/OCC cases compared to LC cases. Conclusions: Our results support a role for HPV‐16 in a subset of HNSCC, corroborate the heterogeneity observed in samples from different countries, and contribute additional etiological and biomarkers information in tumors of significant impact worldwide.