Characterization of T lymphocytes in severe COVID‐19 patients. Issue 9 (3rd May 2021)

• Record Type: Journal Article
• Authors: Fenoglio, Daniela; Dentone, Chiara; Parodi, Alessia; Di Biagio, Antonio; Bozzano, Federica; Vena, Antonio; Fabbi, Marina; Ferrera, Francesca; Altosole, Tiziana; Bruzzone, Bianca; Giacomini, Mauro; Pelosi, Paolo; De Maria, Andrea; Bassetti, Matteo; De Palma, Raffaele; Filaci, Gilberto
• Other Names: Luo Guangxiang (George) guestEditor.; Ly Hinh guestEditor.; Gao Shou‐Jiang guestEditor.
• Is Part Of: Journal of medical virology. Volume 93:Issue 9(2021)
• Page Start: 5608
• Page End: 5613
• Publication Date: 2021-05-03
• Subjects: adaptive immunity -- COVID‐19 -- SARS‐CoV‐2 -- T lymphocytes; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.27037
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract: In this observational study, 13 patients with severe COVID‐19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID‐19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy. Highlights: In patients with severe COVID‐19 we found a relative expansion of T‐cell subsets (Th2‐ and Th17‐ oriented TFH and CD8+ Treg) with a relative reduction of Th1 cells, which are those associated with eradication of a viral infection. This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.