CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives. Issue 9 (28th January 2019)

• Record Type: Journal Article
• Authors: Soleimani, Anvar; Taghizadeh, Eskandar; Shahsavari, Shirin; Amini, Yousef; Rashidpour, Hatam; Azadian, Esmaeel; Jafari, Arash; Parizadeh, Mohammad Reza; Mashayekhi, Kazem; Soukhtanloo, Mohammad; Jaafari, Mahmoud Reza
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 9(2019:Sep.)
• Page Start: 14622
• Page End: 14632
• Publication Date: 2019-01-28
• Subjects: breast cancer -- CD73 -- ectonucleotidase -- tumor microenvironment (TME); Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28187
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Tumor cell invasion and metastasis are the definitive cause of mortality in breast cancer (BC). Hypoxia and pro‐inflammatory cytokines upregulate the CD73 gene in the tumor microenvironment. Subsequently, CD73 triggers molecular and cellular signaling pathways by both enzymatic and nonenzymatic pathways, which finally leads to breast tumor progression and development. In this paper, we summarize current advances in the understanding of CD73‐driven mechanisms that promote BC development and mortality. Furthermore, we evaluate the therapeutic potential of CD73 targeting in BC. Abstract : CD73 ectonucleotidase is upregulated in hypoxic and inflammatory microenvironment of breast cancer (BC). Subsequently, CD73 through both enzymatic and nonenzymatic function leads to breast tumor progression.