Neurodevelopmental outcomes at 3 years for infants with congenital heart disease and very‐low birthweight. Issue 7 (22nd June 2020)

• Record Type: Journal Article
• Authors: Yoshida, Taketoshi; Hiraiwa, Akiko; Ibuki, Keijiro; Makimoto, Masami; Inomata, Satomi; Tamura, Kentaro; Kawasaki, Yukako; Ozawa, Sayaka; Hirono, Keiichi; Ichida, Fukiko
• Is Part Of: Pediatrics international. Volume 62:Issue 7(2020)
• Page Start: 797
• Page End: 803
• Publication Date: 2020-06-22
• Subjects: Bayley Scales -- congenital heart disease -- neurodevelopmental outcomes -- very‐low‐birthweight infant; Pediatrics -- Periodicals; 618.92
• DOI: 10.1111/ped.14160
• Languages: English
• ISSNs: 1328-8067

Abstract

Abstract: Background: Both congenital heart disease (CHD) and very‐low birthweight (VLBW) infants are at a very high risk of neurodevelopmental delay. We investigated neurological development at 3 years in pediatric patients with CHD after surgical intervention, those of VLBW, and healthy controls. Methods: We enrolled pediatric patients with CHD ( n = 67), VLBW ( n = 67), and healthy controls ( n = 81). Infants with CHD were grouped into those with single ventricle and two ventricles, and infants with VLBW were grouped into those with birthweights of <1000 and 1000–1499 g. Neurodevelopmental outcomes at 3 years were evaluated using the Bayley Scales of Infant and Toddler Development, Third Edition. Results: Compared with healthy controls, a significant deficit in the language, cognition, and motor skills scores were observed in infants with CHD and VLBW. Infants with a single ventricle exhibited significantly low scores in language and gross motor skills. No statistically significant difference was observed between the birthweight groups of <1000 and 1000–1499 g. Conclusion: Neurodevelopmental outcomes for infants with both CHD and VLBW showed impairment. Notably, neurodevelopmental delays in infants with a single ventricle were remarkable. Thus, because infants with both CHD and VLBW are at high risk of neurodevelopmental disorders, periodic developmental screenings and support are warranted for these children.