The roles of signaling pathways in liver repair and regeneration. Issue 9 (15th February 2019)

• Record Type: Journal Article
• Authors: Valizadeh, Amir; Majidinia, Maryam; Samadi‐Kafil, Hossein; Yousefi, Mehdi; Yousefi, Bahman
• Is Part Of: Journal of cellular physiology. Volume 234:Issue 9(2019:Sep.)
• Page Start: 14966
• Page End: 14974
• Publication Date: 2019-02-15
• Subjects: FGF -- hippo/YAP -- IGF‐1 -- NF‐kB -- PI3K/AKT -- TGF‐β -- VEGF; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.28336
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: The liver has remarkable regeneration potency that restores liver mass and sustains body hemostasis. Liver regeneration through signaling pathways following resection or moderate damages are well studied. Various cell signaling, growth factors, cytokines, receptors, and cell types implicated in liver regeneration undergo controlled hypertrophy and proliferation. Some aspects of liver regeneration have been discovered and many investigations have been carried out to identify its mechanisms. However, for optimizing liver regeneration more should be understood about mechanisms that control the growth of hepatocytes and other liver cell types in adults. The current paper deals with the possible applicability of liver regeneration signaling pathways as a target for therapeutic approaches and preventing various liver damages. Furthermore, the latest findings of spectrum‐specific signaling pathway mechanisms that underlie liver regeneration are briefly described. Abstract : In this manuscript, we discussed in detail, the involvement of the various key molecular signaling pathways in liver repair and regeneration including Hippo/Yap, PI3K/AKT, VEGF, IGF‐1, NF‐kB, FGF, and TGF‐β