Biodegradable Polymer with Effective Near‐Infrared‐II Absorption as a Photothermal Agent for Deep Tumor Therapy. Issue 4 (28th November 2021)

• Record Type: Journal Article
• Authors: Yu, Yingjie; Tang, Dongsheng; Liu, Chaoyong; Zhang, Qi; Tang, Lin; Lu, Yunfeng; Xiao, Haihua
• Is Part Of: Advanced materials. Volume 34:Issue 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-11-28
• Subjects: biodegradability -- NIR‐II window -- ovarian cancer model -- photothermal agents -- photothermal therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202105976
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Photothermal therapy holds great promise for cancer treatment due to its effective tumor ablation and minimal invasiveness. Herein a new class of biodegradable photothermal agents with effective adsorption in both near‐infrared‐I (NIR‐I) and NIR‐II windows is reported for deep tumor therapy. As demonstrated in a deep‐seated ovarian cancer model, photothermal therapy using 1064 nm irradiation effectively inhibits tumor progression and prolongs survival spans. This work provides a new design of photothermal agents toward a more effective therapy of tumors. Abstract : A biodegradable photothermal agent is developed by inserting cleavable disulfide moieties into a conjugative polymer, which affords biodegradability and excellent adsorption in both the near‐infrared (NIR)‐I and NIR‐II windows, effectively inhibits tumor progression, and extends survival spans in a deep‐seated ovarian cancer mouse model.