Guanidine based copper(II) complexes: synthesis, structural elucidation, and biological evaluation. Issue 5 (23rd May 2022)

• Record Type: Journal Article
• Authors: Said, Muhammad; Khan, Hizbullah; Murtaza, Ghulam; Sirajuddin, Muhammad; Badshah, Amin; Salman, Syed Muhammad; Gul, Rukhsana; , Najeebullah
• Is Part Of: Inorganic and nano-metal chemistry. Volume 53:Issue 5(2023)
• Page Start: 513
• Page End: 522
• Publication Date: 2022-05-23
• Subjects: Guanidine ligand -- Copper(II) complex -- single crystal X-ray diffraction -- antitumor assay -- urease inhibition; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: 10.1080/24701556.2022.2081185
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: Cu(II) complexes of substituted Guanidines having common formula [κ 2 (O, N)-C6 H5 CONHC(NHR 1 )NR 2 ]2 Cu(II), in which R 1 = C6 H5 – and R 2 = C(CH3 )3 (1 ), CH2 CH2 CH3 (2 ), CH(CH3 )2 (3 ), 2, 6-Cl2 C6 H3 (4 ) and 4-CH3 C6 H4 (5 ) were synthesized and their structural and chemical characteristics were examined by CHN analyzer, FTIR, NMR Spectrometer (including 1 H and 13 C) and magnetic susceptibility balance. Two of the guanidine ligands and their Cu(II) complexes were also analyzed by single crystal X-ray diffraction. The X-ray diffraction analysis revealed that majority of the studied guanidine ligands were stable due to intermolecular and intra-molecular hydrogen bonding. The synthesized compounds are mononuclear having pseudo square planar geometry, whereas guanidine ligands attached to the metal center via oxygen and nitrogen atoms. The metallodrugs demonstrated better urease inhibition action than their parent guanidine ligands and also have shown fairly good score regarding the potato disk bioassay in comparison with the vincristine, employed as a standard drug.