Environmentally benign synthesis of 2, 3, 7-Substituted 1, 8-Naphthyridines devoid of catalyst. (2023)

• Record Type: Journal Article
• Authors: Pittala, Bhaskar; Dachepally, Srinivas Reddy; Kethireddy, Shashikala; Eppakayala, Janardhan; Eppakayala, Laxminarayana
• Is Part Of: Materials today. Volume 80:Part 2(2023)
• Page Start: 681
• Page End: 684
• Publication Date: 2023
• Subjects: 2-aminonicotinaldehyde -- PEG: 400 -- Friedlander annulation -- Green synthesis -- 1, 8-Naphthyridines; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2022.11.068
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: A series of 1, 8-Naphthyridines were synthesized from the starting material, 2-Aminonicotinaldehyde (also called as 2-amino- Pyridine-3- carbox aldehyde) through Friedlander annulation. The reaction proceeds in presence of eco-friendly reusable Poly Ethyelene Glycol-400(PEG:400) solvent in catalyst free conditions, shorter reaction times and in good yields. All the synthesized compounds were characterized by IR, 1 H NMR and Mass spectral analyses.