Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context. Issue 12 (12th March 2023)

• Record Type: Journal Article
• Authors: Liu, Yao; Niu, Lili; Li, Nannan; Wang, Yang; Liu, Mingyang; Su, Xiaomin; Bao, Xuhui; Yin, Bo; Shen, Shun
• Is Part Of: Advanced science. Volume 10:Issue 12(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-12
• Subjects: bacteria -- bacterial components -- engineered bacteria -- immunotherapy -- tumor microenvironment; Science -- Periodicals; 505
• DOI: 10.1002/advs.202205641
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Targeted therapy and immunotherapy have brought hopes for precision cancer treatment. However, complex physiological barriers and tumor immunosuppression result in poor efficacy, side effects, and resistance to antitumor therapies. Bacteria‐mediated antitumor therapy provides new options to address these challenges. Thanks to their special characteristics, bacteria have excellent ability to destroy tumor cells from the inside and induce innate and adaptive antitumor immune responses. Furthermore, bacterial components, including bacterial vesicles, spores, toxins, metabolites, and other active substances, similarly inherit their unique targeting properties and antitumor capabilities. Bacteria and their accessory products can even be reprogrammed to produce and deliver antitumor agents according to clinical needs. This review first discusses the role of different bacteria in the development of tumorigenesis and the latest advances in bacteria‐based delivery platforms and the existing obstacles for application. Moreover, the prospect and challenges of clinical transformation of engineered bacteria are also summarized. Abstract : This review first discusses the role of different bacteria in the development of tumorigenesis and the latest advances in bacteria‐based delivery platforms and the existing obstacles for application. Moreover, the prospect and challenges of clinical transformation of engineered bacteria are also summarized.