Multisystem Inflammatory Syndrome in Children in Western Countries? Decreasing Incidence as the Pandemic Progresses?: An Observational Multicenter International Cross-sectional Study. Issue 12 (21st October 2022)

• Record Type: Journal Article
• Authors: Buonsenso, Danilo; Perramon, Aida; Català, Martí; Torres, Juan P.; Camacho-Moreno, Germán; Rojas-Solano, Mariela; Ulloa-Gutierrez, Rolando; Camacho-Badilla, Kattia; Pérez-Corrales, Cristian; Cotugno, Nicola; Yamazaki-Nakashimada, Marco A.; Estripeaut, Dora; Buddingh, Emilie Pauline; von Asmuth, Erik; van Rossum, Annemarie M.C.; Soler-Palacin, Pere; Rivière, Jacques G.; Prats, Clara; Pino, Rosa; Paredes-Carmona, Fernando; Visa-Reñé, Núria; García-Salido, Alberto; Martínez-Mejias, Abel; Soriano-Arandes, Antoni
• Is Part Of: Pediatric infectious disease journal. Volume 41:Issue 12(2022)
• Page Start: 989
• Page End: 993
• Publication Date: 2022-10-21
• Subjects: COVID-19 -- multisystemic inflammatory syndrome in children -- children -- incidence -- epidemiology; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000003713
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Background: SARS-CoV-2 variations as well as immune protection after previous infections and/or vaccination may have altered the incidence of multisystemic inflammatory syndrome in children (MIS-C). We aimed to report an international time-series analysis of the incidence of MIS-C to determine if there was a shift in the regions or countries included into the study. Methods: This is a multicenter, international, cross-sectional study. We collected the MIS-C incidence from the participant regions and countries for the period July 2020 to November 2021. We assessed the ratio between MIS-C cases and COVID-19 pediatric cases in children <18 years diagnosed 4 weeks earlier (average time for the temporal association observed in this disease) for the study period. We performed a binomial regression analysis for 8 participating sites [Bogotá (Colombia), Chile, Costa Rica, Lazio (Italy), Mexico DF, Panama, The Netherlands and Catalonia (Spain)]. Results: We included 904 cases of MIS-C, among a reference population of 17, 906, 432 children. We estimated a global significant decrease trend ratio in MIS-C cases/COVID-19 diagnosed cases in the previous month ( P < 0.001). When analyzing separately each of the sites, Chile and The Netherlands maintained a significant decrease trend ( P < 0.001), but this ratio was not statistically significant for the rest of sites. Conclusions: To our knowledge, this is the first international study describing a global reduction in the trend of the MIS-C incidence during the pandemic. COVID-19 vaccination and other factors possibly linked to the virus itself and/or community transmission may have played a role in preventing new MIS-C cases.