Brønsted Acid Promoted Facile Synthesis of Benzoacridines from Aromatic Aldehydes and N‐Phenyl Naphthylamines. Issue 4 (22nd March 2023)

• Record Type: Journal Article
• Authors: Chen, Ting; Tan, Bin; Huang, Zhi; Mao, Guojiang; Chen, Shanping; Deng, Guo‐Jun
• Is Part Of: Chemistry & biodiversity. Volume 20:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-22
• Subjects: annulation -- dehydrogenation -- metal-free -- nitrogen heterocycles -- oxidation; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202300122
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: A facile method for the rapid synthesis of benzoacridines has been described. This protocol promoted by p‐ toluenesulfonic acid starts from aromatic aldehydes and N ‐phenyl naphthylamines, affording a variety of benzoacridines in 30–90 % yields under metal‐free conditions. The present approach involves a cascade of condensation, Friedel‐Crafts alkylation, annulation and dehydroaromatization in one pot. Abstract : A convenient and practical method for the rapid synthesis of benzoacridines has been described. The present protocol promoted by p‐ toluenesulfonic acid starts from aromatic aldehydes and N ‐phenyl naphthylamines, affording a variety of benzoacridines in satisfactory yields under simple and metal‐free conditions.