Toluene-induced leukodystrophy from glue sniffing. Issue 5 (26th May 2021)

• Record Type: Journal Article
• Authors: Lau, Yue Hui; Mawardi, Ahmad Shahir; Zain, Norzaini Rose; Viswanathan, Shanthi
• Is Part Of: Practical neurology. Volume 21:Issue 5(2021)
• Page Start: 439
• Page End: 441
• Publication Date: 2021-05-26
• Subjects: toluene -- bagging -- leukodystrophy -- cerebral atrophy -- encephalopathy; Neurology -- Periodicals; 616.8005
• DOI: 10.1136/practneurol-2021-002942
• Languages: English
• ISSNs: 1474-7758

Abstract

Abstract : A 33-year-old man with a history of chronic toluene abuse through glue sniffing, developed tremors, cerebellar signs and cognitive decline. MR scan of the brain showed global cerebral and cerebellar atrophy with symmetrical T2-weighted hypointensities in the basal ganglia, thalami and midbrain. After stopping glue sniffing, his tremors, ataxia of gait, speech and cognition partially improved. Early recognition and intervention of toluene-induced leukodystrophy could prevent ongoing morbidity and premature mortality.