Ammonium acetate mediated simple, rapid, and one-pot multicomponent synthesis of spirooxindole derivatives. Issue 11 (3rd June 2023)

• Record Type: Journal Article
• Authors: Raheja, Barkha K.; Dalal, Dipak S.
• Is Part Of: Synthetic communications. Volume 53:Issue 11(2023)
• Page Start: 808
• Page End: 822
• Publication Date: 2023-06-03
• Subjects: Ammonium acetate -- isatin -- multicomponent reaction -- room temperature -- spirooxindoles -- stirring; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2023.2199357
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: Synthesis of spirooxindole derivatives was achieved by combining Knoevenagel condensation and Michael addition between isatin, malononitrile, and dimedone or cyclohexan-1, 3-dione in presence of ammonium acetate by simple stirring in ethanol at room temperature. Spirooxindole derivatives possess promising biological activities like antitumor, antifungal, antimalarial, and anti-HIV. The analytically pure spirooxindoles formed in a concise reaction time without recrystallization or column chromatography. This method is safe and avoids the use of toxic chemicals and excess consumption of energy. Graphical Abstract: UF0001