Cover Feature: Concentration‐Dependent Inhibition of Mesophilic PETases on Poly(ethylene terephthalate) Can Be Eliminated by Enzyme Engineering (ChemSusChem 8/2023). Issue 8 (19th April 2023)

• Record Type: Journal Article
• Authors: Avilan, Luisana; Lichtenstein, Bruce R.; König, Gerhard; Zahn, Michael; Allen, Mark D.; Oliveira, Liliana; Clark, Matilda; Bemmer, Victoria; Graham, Rosie; Austin, Harry P.; Dominick, Graham; Johnson, Christopher W.; Beckham, Gregg T.; McGeehan, John E.; Pickford, Andrew R.
• Is Part Of: ChemSusChem. Volume 16:Issue 8(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-04-19
• Subjects: biocatalysis -- hydrolases -- mesophilic enzymes -- PETase -- plastics; Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.202300472
• Languages: English
• ISSNs: 1864-5631

Abstract

Abstract : The Cover Feature shows the effect of concentration dependent inhibition of natural enzymes that break down poly(ethylene terephthalate) (PET), a polymer widely used in consumer packaging and which contributes to plastic pollution. Mesophilic enzymes (depicted on the right), such as IsPETase from Ideonella sakaiensis, are inhibited as the enzyme concentration increases. In contrast, enzymes engineered to be thermostable (depicted on the left), are not susceptible to this inhibition and can degrade PET at high enzyme concentration. More information can be found in the Research Article by L. Avilan et al . Image credit: Scivetica/Rita Clare.